TY - JOUR
T1 - Increased Risk of Preterm Birth among Women with Mitral Valve Prolapse
T2 - A Nationwide, Population-Based Study
AU - Chen, Chao Hung
AU - Huang, Ming Chao
AU - Liu, Hung Chang
AU - Huang, Chang Jer
AU - Lin, Herng Ching
AU - Kou, Yu Ru
PY - 2011/6
Y1 - 2011/6
N2 - Purpose: Using nationwide population-based databases, we aimed to assess the association between mitral valve prolapse (MVP) and adverse pregnancy outcomes. Methods: The Taiwan Birth Registry and the National Health Insurance Research Dataset were used for analysis. Of all pregnant women in Taiwan who had singleton births in 2005, we identified a total of 3104 mothers diagnosed with MVP during ambulatory or emergency care visits, together with 12,245 mothers unaffected by MPV. Multivariate logistic regression was performed. Results: Multivariate logistic regressions showed that, compared with unaffected mothers, the adjusted odds ratios of preterm birth and cesarean section for mothers with MVP were 1.27 (95% confidence interval [CI], 1.10-1.48) and 1.34 (95% CI, 1.20-1.50), respectively. In further stratification based on the timing of the MVP diagnosis, the highest risks of preterm birth were observed for mothers diagnosed with MVP during (but not before) pregnancy (odds ratio [OR], 1.54; p = .001). No significant difference was observed between women with and without MVP for other outcomes such as low birthweight, intrapartum complications, low Apgar scores, and congenital malformations. Conclusions: Our study found a significant risk of preterm delivery among women with MVP. A multidisciplinary team approach to providing obstetric care, with the mission of monitoring signs of cardiac complications and preterm birth, is imperative.
AB - Purpose: Using nationwide population-based databases, we aimed to assess the association between mitral valve prolapse (MVP) and adverse pregnancy outcomes. Methods: The Taiwan Birth Registry and the National Health Insurance Research Dataset were used for analysis. Of all pregnant women in Taiwan who had singleton births in 2005, we identified a total of 3104 mothers diagnosed with MVP during ambulatory or emergency care visits, together with 12,245 mothers unaffected by MPV. Multivariate logistic regression was performed. Results: Multivariate logistic regressions showed that, compared with unaffected mothers, the adjusted odds ratios of preterm birth and cesarean section for mothers with MVP were 1.27 (95% confidence interval [CI], 1.10-1.48) and 1.34 (95% CI, 1.20-1.50), respectively. In further stratification based on the timing of the MVP diagnosis, the highest risks of preterm birth were observed for mothers diagnosed with MVP during (but not before) pregnancy (odds ratio [OR], 1.54; p = .001). No significant difference was observed between women with and without MVP for other outcomes such as low birthweight, intrapartum complications, low Apgar scores, and congenital malformations. Conclusions: Our study found a significant risk of preterm delivery among women with MVP. A multidisciplinary team approach to providing obstetric care, with the mission of monitoring signs of cardiac complications and preterm birth, is imperative.
KW - Mitral Valve Prolapse
KW - Pregnancy Outcomes
KW - Preterm Birth
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U2 - 10.1016/j.annepidem.2011.02.004
DO - 10.1016/j.annepidem.2011.02.004
M3 - Article
C2 - 21435902
AN - SCOPUS:79955600661
SN - 1047-2797
VL - 21
SP - 391
EP - 398
JO - Annals of Epidemiology
JF - Annals of Epidemiology
IS - 6
ER -