Increased risk of periodontitis among patients with Crohn’s disease: a population-based matched-cohort study

Ying Chen Chi, Jiunn Liang Chen, Li Hsuan Wang, Koyin Chang, Chen Long Wu, Shu Yi Lin, Joseph Jordan Keller, Chyi Huey Bai

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Background: Periodontitis is a frequently cited extraintestinal manifestation of Crohn’s disease (CD). Despite a plethora of investigations and a recent meta-analysis linking CD and periodontitis, no study has estimated the risk of periodontitis among CD patients with respect to a comparison group nor has any investigation analyzed the effect of CD-specific medications on the risk of periodontitis. The present cohort study compared CD patients and matched subjects without a history of inflammatory bowel disease (IBD) to estimate the effect of CD and CD-specific pharmaceutical prescriptions on the risk of developing periodontitis by leveraging a population-based dataset in Taiwan. Methods: We sourced 6657 CD patients and 26,628 comparison subjects without a history of IBD from the Taiwan National Health Insurance Database. Cox proportional hazards regressions were used to estimate the risk of subsequent periodontitis by CD status and pharmaceutical prescription during the follow-up period. Results: After adjusting for socioeconomic status (SES), urbanicity, selected medical co-morbidities, and CD-specific pharmaceutical prescriptions, the hazard ratio (HR) for subsequent periodontitis among patients with CD was 1.36 (95% CI = 1.25–1.48) that of comparison subjects. There was not a significant difference in risk between genders or across ages. Steroids (95% CI = 0.66–0.77) appeared to confer a protective effect and Aspirin, Plavix, and Licodin were marginally protective (95% CI = 0.76–0.95). Conclusion: This is the first study to report an increased HR for subsequent periodontitis among CD patients when compared to matched comparison subjects without IBD. The protective effect of some pharmaceuticals may suggest that treatment of CD protects against periodontitis.

Original languageEnglish
Pages (from-to)1437-1444
Number of pages8
JournalInternational Journal of Colorectal Disease
Issue number10
Publication statusPublished - Oct 1 2018


  • Crohn’s disease
  • Epidemiology
  • Periodontitis

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Increased risk of periodontitis among patients with Crohn’s disease: a population-based matched-cohort study'. Together they form a unique fingerprint.

Cite this