TY - JOUR
T1 - Increased risk of ischemic stroke among women with bladder pain syndrome/interstitial cystitis
T2 - A cohort study from Taiwan
AU - Chung, Shiu Dong
AU - Xirasagar, Sudha
AU - Lin, Ching Chun
AU - Ling, Wells
AU - Li, Hsien-Chang
AU - Lin, Herng Ching
N1 - Publisher Copyright:
© 2013 The Authors. Neurourology & Urodynamics published by Wiley Periodicals, Inc.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Aim Vascular factors are proposed in the etiology of bladder pain syndrome/interstitial cystitis (BPS/IC). In this study, we investigated the risk of stroke among women following a diagnosis of BPS/IC over 3 years of follow-up, compared to controls without a BPS/IC diagnosis.Methods This retrospective cohort study used data retrieved from the Taiwan "Longitudinal Health Insurance Database 2000." We identified 847 women who received a diagnosis of BPS/IC between January 1, 2001 and December 31, 2008 (study group) and 4,235 comparison women (women without a BPS/IC diagnosis matched on age and other selected demographic variables. All subjects were tracked for 3 years following the index date to identify those who received a diagnosis of stroke during follow-up.Results The stroke incidence rate was 20.86 (95% confidence interval (CI): 15.78-27.07) and 11.65 (95% CI: 9.88-13.64) per 1,000 person-years among the study and comparison cohorts, respectively. Cox regression analysis showed a stroke hazard ratio (HR) of 1.52 (95% CI: 1.09-2.14) in the BPS/IC group relative to the comparison group over 3-year follow-up, after adjusting for hypertension, diabetes, coronary heart disease, atrial fibrillation, hyperlipidemia, and chronic kidney disease. The adjusted HR of ischemic stroke was 1.52 (95% CI: 1.02-2.27). However, there was no significant difference between the two groups in hemorrhagic stroke risk.Conclusions Our study demonstrates an association between BPS/IC and a subsequent ischemic stroke diagnosis among women in Taiwan. Neurourol. Urodynam. 34:44-49, 2015.
AB - Aim Vascular factors are proposed in the etiology of bladder pain syndrome/interstitial cystitis (BPS/IC). In this study, we investigated the risk of stroke among women following a diagnosis of BPS/IC over 3 years of follow-up, compared to controls without a BPS/IC diagnosis.Methods This retrospective cohort study used data retrieved from the Taiwan "Longitudinal Health Insurance Database 2000." We identified 847 women who received a diagnosis of BPS/IC between January 1, 2001 and December 31, 2008 (study group) and 4,235 comparison women (women without a BPS/IC diagnosis matched on age and other selected demographic variables. All subjects were tracked for 3 years following the index date to identify those who received a diagnosis of stroke during follow-up.Results The stroke incidence rate was 20.86 (95% confidence interval (CI): 15.78-27.07) and 11.65 (95% CI: 9.88-13.64) per 1,000 person-years among the study and comparison cohorts, respectively. Cox regression analysis showed a stroke hazard ratio (HR) of 1.52 (95% CI: 1.09-2.14) in the BPS/IC group relative to the comparison group over 3-year follow-up, after adjusting for hypertension, diabetes, coronary heart disease, atrial fibrillation, hyperlipidemia, and chronic kidney disease. The adjusted HR of ischemic stroke was 1.52 (95% CI: 1.02-2.27). However, there was no significant difference between the two groups in hemorrhagic stroke risk.Conclusions Our study demonstrates an association between BPS/IC and a subsequent ischemic stroke diagnosis among women in Taiwan. Neurourol. Urodynam. 34:44-49, 2015.
KW - bladder pain syndrome/interstitial cystitis
KW - interstitial cystitis
KW - stroke
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U2 - 10.1002/nau.22515
DO - 10.1002/nau.22515
M3 - Article
C2 - 24155221
AN - SCOPUS:84916878364
SN - 0733-2467
VL - 34
SP - 44
EP - 49
JO - Neurourology and Urodynamics
JF - Neurourology and Urodynamics
IS - 1
ER -
