TY - JOUR
T1 - Increased risk of adverse pregnancy outcomes in women with rheumatoid arthritis
T2 - A nationwide population-based study
AU - Lin, Herng Ching
AU - Chen, Shu Fen
AU - Lin, Hsiu Chen
AU - Chen, Yi Hua
PY - 2010/4
Y1 - 2010/4
N2 - Objective: Using a 3-year nationwide population-based database (2001-3), this study aims to examine the relationship between rheumatoid arthritis (RA) and adverse pregnancy outcomes. Methods: The study used the Taiwan National Health Insurance Research Dataset and birth certificate registry. In total, 1912 mothers with RA and 9560 matched comparison mothers were included. Separate conditional logistic regression analyses were carried out to explore the risk of low birthweight (LBW), preterm births, small for gestational age (SGA) infants, preeclampsia and delivery mode (vaginal vs caesarean section (CS)) for the study and comparison groups. Results: Regression analyses showed that the adjusted odds of LBW, SGA infants, preeclampsia and CS for women with RA were 1.47 (95% CI 1.22 to 1.78), 1.20 (95% CI 1.05 to 1.38), 2.22 (95% CI 1.59 to 3.11) and 1.19 (95% CI 1.07 to 1.31) times, respectively, that of comparison mothers. Conclusion: Women with RA had an increased risk of LBW, SGA babies, preeclampsia and CS compared with unaffected women.
AB - Objective: Using a 3-year nationwide population-based database (2001-3), this study aims to examine the relationship between rheumatoid arthritis (RA) and adverse pregnancy outcomes. Methods: The study used the Taiwan National Health Insurance Research Dataset and birth certificate registry. In total, 1912 mothers with RA and 9560 matched comparison mothers were included. Separate conditional logistic regression analyses were carried out to explore the risk of low birthweight (LBW), preterm births, small for gestational age (SGA) infants, preeclampsia and delivery mode (vaginal vs caesarean section (CS)) for the study and comparison groups. Results: Regression analyses showed that the adjusted odds of LBW, SGA infants, preeclampsia and CS for women with RA were 1.47 (95% CI 1.22 to 1.78), 1.20 (95% CI 1.05 to 1.38), 2.22 (95% CI 1.59 to 3.11) and 1.19 (95% CI 1.07 to 1.31) times, respectively, that of comparison mothers. Conclusion: Women with RA had an increased risk of LBW, SGA babies, preeclampsia and CS compared with unaffected women.
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U2 - 10.1136/ard.2008.105262
DO - 10.1136/ard.2008.105262
M3 - Article
C2 - 19406733
AN - SCOPUS:77950308664
SN - 0003-4967
VL - 69
SP - 715
EP - 717
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
IS - 4
ER -