Increased Risk of Active Tuberculosis following Acute Kidney Injury: A Nationwide, Population-Based Study

Vin Cent Wu, Chen Yi Wang, Chih Chung Shiao, Chia Hsui Chang, Hui Yu Huang, Tao Min Huang, Chun Fu Lai, Meng Chun Lin, Wen Je Ko, Kwan Dun Wu, Chong Jen Yu, Chin Chung Shu, Chih Hsin Lee, Jann Yuan Wang

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Background:Profound alterations in immune responses associated with uremia and exacerbated by dialysis increase the risk of active tuberculosis (TB). Evidence of the long-term risk and outcome of active TB after acute kidney injury (AKI) is limited.Methods:This population-based-cohort study used claim records retrieved from the Taiwan National Health Insurance database. We retrieved records of all hospitalized patients, more than 18 years, who underwent dialysis for acute kidney injury (AKI) during 1999-2008 and validated using the NSARF data. Time-dependent Cox proportional hazards model to adjust for the ongoing effect of end-stage renal disease (ESRD) was conducted to predict long-term de novo active TB after discharge from index hospitalization.Results:Out of 2,909 AKI dialysis patients surviving 90 days after index discharge, 686 did not require dialysis after hospital discharge. The control group included 11,636 hospital patients without AKI, dialysis, or history of TB. The relative risk of active TB in AKI dialysis patients, relative to the general population, after a mean follow-up period of 3.6 years was 7.71. Patients who did (hazard ratio [HR], 3.84; p

Original languageEnglish
Article numbere69556
JournalPLoS One
Issue number7
Publication statusPublished - Jul 25 2013
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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