Increased Risk of Active Tuberculosis following Acute Kidney Injury: A Nationwide, Population-Based Study

Vin Cent Wu; Chen Yi Wang; Chih Chung Shiao; Chia Hsui Chang; Hui Yu Huang; Tao Min Huang; Chun Fu Lai; Meng Chun Lin; Wen Je Ko; Kwan Dun Wu; Chong Jen Yu; Chin Chung Shu; Chih Hsin Lee; Jann Yuan Wang

doi:10.1371/journal.pone.0069556

Increased Risk of Active Tuberculosis following Acute Kidney Injury: A Nationwide, Population-Based Study

Vin Cent Wu, Chen Yi Wang, Chih Chung Shiao, Chia Hsui Chang, Hui Yu Huang, Tao Min Huang, Chun Fu Lai, Meng Chun Lin, Wen Je Ko, Kwan Dun Wu, Chong Jen Yu, Chin Chung Shu, Chih Hsin Lee, Jann Yuan Wang

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Background:Profound alterations in immune responses associated with uremia and exacerbated by dialysis increase the risk of active tuberculosis (TB). Evidence of the long-term risk and outcome of active TB after acute kidney injury (AKI) is limited.Methods:This population-based-cohort study used claim records retrieved from the Taiwan National Health Insurance database. We retrieved records of all hospitalized patients, more than 18 years, who underwent dialysis for acute kidney injury (AKI) during 1999-2008 and validated using the NSARF data. Time-dependent Cox proportional hazards model to adjust for the ongoing effect of end-stage renal disease (ESRD) was conducted to predict long-term de novo active TB after discharge from index hospitalization.Results:Out of 2,909 AKI dialysis patients surviving 90 days after index discharge, 686 did not require dialysis after hospital discharge. The control group included 11,636 hospital patients without AKI, dialysis, or history of TB. The relative risk of active TB in AKI dialysis patients, relative to the general population, after a mean follow-up period of 3.6 years was 7.71. Patients who did (hazard ratio [HR], 3.84; p

Original language	English
Article number	e69556
Journal	PLoS One
Volume	8
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0069556
Publication status	Published - Jul 25 2013
Externally published	Yes

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0069556

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title = "Increased Risk of Active Tuberculosis following Acute Kidney Injury: A Nationwide, Population-Based Study",

abstract = "Background:Profound alterations in immune responses associated with uremia and exacerbated by dialysis increase the risk of active tuberculosis (TB). Evidence of the long-term risk and outcome of active TB after acute kidney injury (AKI) is limited.Methods:This population-based-cohort study used claim records retrieved from the Taiwan National Health Insurance database. We retrieved records of all hospitalized patients, more than 18 years, who underwent dialysis for acute kidney injury (AKI) during 1999-2008 and validated using the NSARF data. Time-dependent Cox proportional hazards model to adjust for the ongoing effect of end-stage renal disease (ESRD) was conducted to predict long-term de novo active TB after discharge from index hospitalization.Results:Out of 2,909 AKI dialysis patients surviving 90 days after index discharge, 686 did not require dialysis after hospital discharge. The control group included 11,636 hospital patients without AKI, dialysis, or history of TB. The relative risk of active TB in AKI dialysis patients, relative to the general population, after a mean follow-up period of 3.6 years was 7.71. Patients who did (hazard ratio [HR], 3.84; p",

author = "Wu, {Vin Cent} and Wang, {Chen Yi} and Shiao, {Chih Chung} and Chang, {Chia Hsui} and Huang, {Hui Yu} and Huang, {Tao Min} and Lai, {Chun Fu} and Lin, {Meng Chun} and Ko, {Wen Je} and Wu, {Kwan Dun} and Yu, {Chong Jen} and Shu, {Chin Chung} and Lee, {Chih Hsin} and Wang, {Jann Yuan}",

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doi = "10.1371/journal.pone.0069556",

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AU - Wu, Vin Cent

AU - Wang, Chen Yi

AU - Shiao, Chih Chung

AU - Chang, Chia Hsui

AU - Huang, Hui Yu

AU - Huang, Tao Min

AU - Lai, Chun Fu

AU - Lin, Meng Chun

AU - Ko, Wen Je

AU - Wu, Kwan Dun

AU - Yu, Chong Jen

AU - Shu, Chin Chung

AU - Lee, Chih Hsin

AU - Wang, Jann Yuan

PY - 2013/7/25

Y1 - 2013/7/25

N2 - Background:Profound alterations in immune responses associated with uremia and exacerbated by dialysis increase the risk of active tuberculosis (TB). Evidence of the long-term risk and outcome of active TB after acute kidney injury (AKI) is limited.Methods:This population-based-cohort study used claim records retrieved from the Taiwan National Health Insurance database. We retrieved records of all hospitalized patients, more than 18 years, who underwent dialysis for acute kidney injury (AKI) during 1999-2008 and validated using the NSARF data. Time-dependent Cox proportional hazards model to adjust for the ongoing effect of end-stage renal disease (ESRD) was conducted to predict long-term de novo active TB after discharge from index hospitalization.Results:Out of 2,909 AKI dialysis patients surviving 90 days after index discharge, 686 did not require dialysis after hospital discharge. The control group included 11,636 hospital patients without AKI, dialysis, or history of TB. The relative risk of active TB in AKI dialysis patients, relative to the general population, after a mean follow-up period of 3.6 years was 7.71. Patients who did (hazard ratio [HR], 3.84; p

AB - Background:Profound alterations in immune responses associated with uremia and exacerbated by dialysis increase the risk of active tuberculosis (TB). Evidence of the long-term risk and outcome of active TB after acute kidney injury (AKI) is limited.Methods:This population-based-cohort study used claim records retrieved from the Taiwan National Health Insurance database. We retrieved records of all hospitalized patients, more than 18 years, who underwent dialysis for acute kidney injury (AKI) during 1999-2008 and validated using the NSARF data. Time-dependent Cox proportional hazards model to adjust for the ongoing effect of end-stage renal disease (ESRD) was conducted to predict long-term de novo active TB after discharge from index hospitalization.Results:Out of 2,909 AKI dialysis patients surviving 90 days after index discharge, 686 did not require dialysis after hospital discharge. The control group included 11,636 hospital patients without AKI, dialysis, or history of TB. The relative risk of active TB in AKI dialysis patients, relative to the general population, after a mean follow-up period of 3.6 years was 7.71. Patients who did (hazard ratio [HR], 3.84; p

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Increased Risk of Active Tuberculosis following Acute Kidney Injury: A Nationwide, Population-Based Study

Abstract

ASJC Scopus subject areas

UN SDGs

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