Increased prevalences of head and neck cancers in patients with Sjögren's syndrome

Tzong Hann Yang, Yen Fu Cheng, Chin Shyan Chen, Herng Ching Lin

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: This study aimed to investigate prevalences of head and neck cancers in patients with and those without Sjögren's syndrome using a population-based dataset. Methods: We retrieved sampled patients from Taiwan's Longitudinal Health Insurance Database. This study included 38 930 patients with Sjögren's syndrome and 155 720 propensity-score matched comparison patients without Sjögren's syndrome. Results: Chi-squared tests revealed that there was a statistically significant difference in the prevalences of head and neck cancers between patients with Sjögren's syndrome and comparison patients (1.77% vs. 1.22%, p < 0.001). The odds ratio for head and neck cancers for patients with Sjögren's syndrome relative to the comparison group was 1.452 (95% CI = 1.325–1.592). Conclusions: Our study demonstrated that patients with Sjögren's syndrome face increased odds of head and neck cancers, encompassing several sites including the oral cavity, oropharynx, nasopharynx, and thyroid.

Original languageEnglish
Pages (from-to)2874-2881
Number of pages8
JournalHead and Neck
Volume45
Issue number11
DOIs
Publication statusPublished - Nov 2023

Keywords

  • epidemiology
  • head and neck cancer
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Otorhinolaryngology

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