Increased Oxidative DNA Damage in Patients With Alcohol Dependence and Its Correlation With Alcohol Withdrawal Severity

Chun Hsin Chen; Chun Hung Pan; Chiao Chicy Chen; Ming Chyi Huang

doi:10.1111/j.1530-0277.2010.01349.x

Increased Oxidative DNA Damage in Patients With Alcohol Dependence and Its Correlation With Alcohol Withdrawal Severity

Chun Hsin Chen, Chun Hung Pan, Chiao Chicy Chen, Ming Chyi Huang

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Background: Chronic and excessive alcohol consumption enhances the formation of reactive oxygen species (ROS) and ethanol-derived free radicals. 8-Hydroxy-2′-deoxyguanosine (8-OHdG) is a marker to estimate ROS-induced DNA damage. The study objective was to compare serum 8-OHdG levels between patients with alcohol dependence and healthy controls and to investigate the correlation between this marker and the severity of alcohol withdrawal syndrome (AWS). Methods: We recruited 79 patients with alcohol dependence and 63 healthy control subjects. The severity of AWS was evaluated using the Chinese version of the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar-C) every 8hours. Levels of 8-OHdG, malondialdehyde (MDA), and other biologic indexes were assayed at baseline for patient and control groups, and after 1-week detoxification for the patient group. Results: The 8-OHdG and MDA levels in the alcoholic group were significantly higher than those in the control group (0.34 vs. 0.27ng/ml and 13.5 vs. 10.1μM, respectively). Both 8-OHdG and MDA were significantly correlated with the highest CIWA-Ar-C (correlation coefficient=0.39, p

Original language	English
Pages (from-to)	338-344
Number of pages	7
Journal	Alcoholism: Clinical and Experimental Research
Volume	35
Issue number	2
DOIs	https://doi.org/10.1111/j.1530-0277.2010.01349.x
Publication status	Published - Feb 2011

Keywords

8-Hydroxy-2′-Deoxyguanosine
Alcohol Dependence
Alcohol Withdrawal
Malondialdehyde
Oxidative Stress

ASJC Scopus subject areas

Medicine (miscellaneous)
Psychiatry and Mental health
Toxicology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1530-0277.2010.01349.x

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title = "Increased Oxidative DNA Damage in Patients With Alcohol Dependence and Its Correlation With Alcohol Withdrawal Severity",

abstract = "Background: Chronic and excessive alcohol consumption enhances the formation of reactive oxygen species (ROS) and ethanol-derived free radicals. 8-Hydroxy-2′-deoxyguanosine (8-OHdG) is a marker to estimate ROS-induced DNA damage. The study objective was to compare serum 8-OHdG levels between patients with alcohol dependence and healthy controls and to investigate the correlation between this marker and the severity of alcohol withdrawal syndrome (AWS). Methods: We recruited 79 patients with alcohol dependence and 63 healthy control subjects. The severity of AWS was evaluated using the Chinese version of the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar-C) every 8hours. Levels of 8-OHdG, malondialdehyde (MDA), and other biologic indexes were assayed at baseline for patient and control groups, and after 1-week detoxification for the patient group. Results: The 8-OHdG and MDA levels in the alcoholic group were significantly higher than those in the control group (0.34 vs. 0.27ng/ml and 13.5 vs. 10.1μM, respectively). Both 8-OHdG and MDA were significantly correlated with the highest CIWA-Ar-C (correlation coefficient=0.39, p",

keywords = "8-Hydroxy-2′-Deoxyguanosine, Alcohol Dependence, Alcohol Withdrawal, Malondialdehyde, Oxidative Stress",

author = "Chen, {Chun Hsin} and Pan, {Chun Hung} and Chen, {Chiao Chicy} and Huang, {Ming Chyi}",

year = "2011",

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doi = "10.1111/j.1530-0277.2010.01349.x",

language = "English",

volume = "35",

pages = "338--344",

journal = "Alcoholism: Clinical and Experimental Research",

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AU - Chen, Chun Hsin

AU - Pan, Chun Hung

AU - Chen, Chiao Chicy

AU - Huang, Ming Chyi

PY - 2011/2

Y1 - 2011/2

N2 - Background: Chronic and excessive alcohol consumption enhances the formation of reactive oxygen species (ROS) and ethanol-derived free radicals. 8-Hydroxy-2′-deoxyguanosine (8-OHdG) is a marker to estimate ROS-induced DNA damage. The study objective was to compare serum 8-OHdG levels between patients with alcohol dependence and healthy controls and to investigate the correlation between this marker and the severity of alcohol withdrawal syndrome (AWS). Methods: We recruited 79 patients with alcohol dependence and 63 healthy control subjects. The severity of AWS was evaluated using the Chinese version of the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar-C) every 8hours. Levels of 8-OHdG, malondialdehyde (MDA), and other biologic indexes were assayed at baseline for patient and control groups, and after 1-week detoxification for the patient group. Results: The 8-OHdG and MDA levels in the alcoholic group were significantly higher than those in the control group (0.34 vs. 0.27ng/ml and 13.5 vs. 10.1μM, respectively). Both 8-OHdG and MDA were significantly correlated with the highest CIWA-Ar-C (correlation coefficient=0.39, p

AB - Background: Chronic and excessive alcohol consumption enhances the formation of reactive oxygen species (ROS) and ethanol-derived free radicals. 8-Hydroxy-2′-deoxyguanosine (8-OHdG) is a marker to estimate ROS-induced DNA damage. The study objective was to compare serum 8-OHdG levels between patients with alcohol dependence and healthy controls and to investigate the correlation between this marker and the severity of alcohol withdrawal syndrome (AWS). Methods: We recruited 79 patients with alcohol dependence and 63 healthy control subjects. The severity of AWS was evaluated using the Chinese version of the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar-C) every 8hours. Levels of 8-OHdG, malondialdehyde (MDA), and other biologic indexes were assayed at baseline for patient and control groups, and after 1-week detoxification for the patient group. Results: The 8-OHdG and MDA levels in the alcoholic group were significantly higher than those in the control group (0.34 vs. 0.27ng/ml and 13.5 vs. 10.1μM, respectively). Both 8-OHdG and MDA were significantly correlated with the highest CIWA-Ar-C (correlation coefficient=0.39, p

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KW - Malondialdehyde

KW - Oxidative Stress

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Increased Oxidative DNA Damage in Patients With Alcohol Dependence and Its Correlation With Alcohol Withdrawal Severity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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