Increased matrix metalloproteinase-9 to tissue inhibitor of metalloproteinase-1 ratio in smokers with airway hyperresponsiveness and accelerated lung function decline

Medicine & Life Sciences

• Tissue Inhibitor of Metalloproteinase-1 100%
• Matrix Metalloproteinase 9 89%
• Alveolar Macrophages 82%
• Smokers 70%
• Lung 44%
• Forced Expiratory Volume 29%
• SB 203580 22%
• Matrix Metalloproteinase Inhibitors 22%
• 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 21%
• Vital Capacity 20%
• Mitogen-Activated Protein Kinase Kinases 20%
• Bronchoalveolar Lavage Fluid 20%
• p38 Mitogen-Activated Protein Kinases 19%
• Non-Smokers 18%
• Chronic Obstructive Pulmonary Disease 16%
• MAP Kinase Kinase 1 13%
• Methacholine Chloride 11%
• Mitogen-Activated Protein Kinase 1 10%
• Spirometry 10%
• Extracellular Signal-Regulated MAP Kinases 10%
• Airway Obstruction 9%
• Protein Kinase Inhibitors 9%
• Neutrophils 7%
• Enzyme-Linked Immunosorbent Assay 6%
• Inflammation 5%