Increased leukocyte Rho-associated coiled-coil containing protein kinase activity predicts the presence and severity of coronary vasospastic angina

Ming Jui Hung; Wen Jin Cherng; Ming Yow Hung; Li Tang Kuo; Chi Wen Cheng; Chao Hung Wang; Ning I. Yang; James K. Liao

doi:10.1016/j.atherosclerosis.2012.01.001

Increased leukocyte Rho-associated coiled-coil containing protein kinase activity predicts the presence and severity of coronary vasospastic angina

Ming Jui Hung, Wen Jin Cherng, Ming Yow Hung, Li Tang Kuo, Chi Wen Cheng, Chao Hung Wang, Ning I. Yang, James K. Liao

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Objective: Although inhibition of Rho-associated coiled-coil containing protein kinase (ROCK) has been shown to prevent coronary vasospastic angina (CVA), direct evidence linking ROCK activity and CVA is lacking. Accordingly, we investigated whether ROCK activity is an independent marker for CVA and is altered after treatment with antispastic medications. Methods and results: We prospectively studied 31 Taiwanese patients who were diagnosed with CVA and 33 control subjects. Subject demographics were recorded, and blood samples were obtained at baseline in all participants and in CVA patients after 3 months of antispastic treatment. Compared with control subjects, leukocyte ROCK activity was greater in CVA patients (136% versus 91%, P

Original language	English
Pages (from-to)	521-526
Number of pages	6
Journal	Atherosclerosis
Volume	221
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2012.01.001
Publication status	Published - Apr 2012

Keywords

Angina
Calcium antagonist
Coronary vasospasm
Rho-kinase

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.atherosclerosis.2012.01.001

Cite this

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title = "Increased leukocyte Rho-associated coiled-coil containing protein kinase activity predicts the presence and severity of coronary vasospastic angina",

abstract = "Objective: Although inhibition of Rho-associated coiled-coil containing protein kinase (ROCK) has been shown to prevent coronary vasospastic angina (CVA), direct evidence linking ROCK activity and CVA is lacking. Accordingly, we investigated whether ROCK activity is an independent marker for CVA and is altered after treatment with antispastic medications. Methods and results: We prospectively studied 31 Taiwanese patients who were diagnosed with CVA and 33 control subjects. Subject demographics were recorded, and blood samples were obtained at baseline in all participants and in CVA patients after 3 months of antispastic treatment. Compared with control subjects, leukocyte ROCK activity was greater in CVA patients (136% versus 91%, P",

keywords = "Angina, Calcium antagonist, Coronary vasospasm, Rho-kinase",

author = "Hung, {Ming Jui} and Cherng, {Wen Jin} and Hung, {Ming Yow} and Kuo, {Li Tang} and Cheng, {Chi Wen} and Wang, {Chao Hung} and Yang, {Ning I.} and Liao, {James K.}",

year = "2012",

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doi = "10.1016/j.atherosclerosis.2012.01.001",

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pages = "521--526",

journal = "Atherosclerosis",

issn = "0021-9150",

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T1 - Increased leukocyte Rho-associated coiled-coil containing protein kinase activity predicts the presence and severity of coronary vasospastic angina

AU - Hung, Ming Jui

AU - Cherng, Wen Jin

AU - Hung, Ming Yow

AU - Kuo, Li Tang

AU - Cheng, Chi Wen

AU - Wang, Chao Hung

AU - Yang, Ning I.

AU - Liao, James K.

PY - 2012/4

Y1 - 2012/4

N2 - Objective: Although inhibition of Rho-associated coiled-coil containing protein kinase (ROCK) has been shown to prevent coronary vasospastic angina (CVA), direct evidence linking ROCK activity and CVA is lacking. Accordingly, we investigated whether ROCK activity is an independent marker for CVA and is altered after treatment with antispastic medications. Methods and results: We prospectively studied 31 Taiwanese patients who were diagnosed with CVA and 33 control subjects. Subject demographics were recorded, and blood samples were obtained at baseline in all participants and in CVA patients after 3 months of antispastic treatment. Compared with control subjects, leukocyte ROCK activity was greater in CVA patients (136% versus 91%, P

AB - Objective: Although inhibition of Rho-associated coiled-coil containing protein kinase (ROCK) has been shown to prevent coronary vasospastic angina (CVA), direct evidence linking ROCK activity and CVA is lacking. Accordingly, we investigated whether ROCK activity is an independent marker for CVA and is altered after treatment with antispastic medications. Methods and results: We prospectively studied 31 Taiwanese patients who were diagnosed with CVA and 33 control subjects. Subject demographics were recorded, and blood samples were obtained at baseline in all participants and in CVA patients after 3 months of antispastic treatment. Compared with control subjects, leukocyte ROCK activity was greater in CVA patients (136% versus 91%, P

KW - Angina

KW - Calcium antagonist

KW - Coronary vasospasm

KW - Rho-kinase

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Increased leukocyte Rho-associated coiled-coil containing protein kinase activity predicts the presence and severity of coronary vasospastic angina

Abstract

Keywords

ASJC Scopus subject areas

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