Abstract
Objective: Although inhibition of Rho-associated coiled-coil containing protein kinase (ROCK) has been shown to prevent coronary vasospastic angina (CVA), direct evidence linking ROCK activity and CVA is lacking. Accordingly, we investigated whether ROCK activity is an independent marker for CVA and is altered after treatment with antispastic medications. Methods and results: We prospectively studied 31 Taiwanese patients who were diagnosed with CVA and 33 control subjects. Subject demographics were recorded, and blood samples were obtained at baseline in all participants and in CVA patients after 3 months of antispastic treatment. Compared with control subjects, leukocyte ROCK activity was greater in CVA patients (136% versus 91%, P
Original language | English |
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Pages (from-to) | 521-526 |
Number of pages | 6 |
Journal | Atherosclerosis |
Volume | 221 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 2012 |
Keywords
- Angina
- Calcium antagonist
- Coronary vasospasm
- Rho-kinase
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine