TY - JOUR
T1 - Increased interleukin-6 in aqueous humor of a patient with lung-metastatic intraocular adenocarcinoma
AU - Chen, Ko Hua
AU - Hsu, Wen Ming
AU - Wu, Chih Chiau
PY - 2003/2/1
Y1 - 2003/2/1
N2 - PURPOSE: We report increased interleukin (IL)-6 level in aqueous humor of a case of lung adenocarcinoma with metastasis to iris and anterior chamber. DESIGN: Interventional case report. METHODS: In one case and 11 healthy cataract patients as controls, we checked the levels of IL-6, IL-2, and tumor necrosis factor (TNF)-α in aqueous humor and serum by enzyme-linked immunosorbent assay. RESULTS: Levels of these three cytokines in serum were almost the same as with the levels in aqueous humor in the control group. The IL-6 concentrations ranged from 12.6 to 27.0 pg/ml (mean, 23.5 pg/ml) in serum and 15.0 to 43.1 pg/ml (mean, 22.4 pg/ml) in aqueous humor. There was no statistically significant difference between them. Compared with the control, the IL-6 concentration in aqueous humor of this patient, 282.0 pg/ml, increased more than 10-fold. CONCLUSION: This is a report describing elevated IL-6 level in the aqueous humor of a patient with intraocular metastasis from lung adenocarcinoma.
AB - PURPOSE: We report increased interleukin (IL)-6 level in aqueous humor of a case of lung adenocarcinoma with metastasis to iris and anterior chamber. DESIGN: Interventional case report. METHODS: In one case and 11 healthy cataract patients as controls, we checked the levels of IL-6, IL-2, and tumor necrosis factor (TNF)-α in aqueous humor and serum by enzyme-linked immunosorbent assay. RESULTS: Levels of these three cytokines in serum were almost the same as with the levels in aqueous humor in the control group. The IL-6 concentrations ranged from 12.6 to 27.0 pg/ml (mean, 23.5 pg/ml) in serum and 15.0 to 43.1 pg/ml (mean, 22.4 pg/ml) in aqueous humor. There was no statistically significant difference between them. Compared with the control, the IL-6 concentration in aqueous humor of this patient, 282.0 pg/ml, increased more than 10-fold. CONCLUSION: This is a report describing elevated IL-6 level in the aqueous humor of a patient with intraocular metastasis from lung adenocarcinoma.
UR - http://www.scopus.com/inward/record.url?scp=0037310464&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037310464&partnerID=8YFLogxK
U2 - 10.1016/S0002-9394(02)01920-7
DO - 10.1016/S0002-9394(02)01920-7
M3 - Article
C2 - 12566037
AN - SCOPUS:0037310464
SN - 0002-9394
VL - 135
SP - 237
EP - 239
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 2
ER -