TY - JOUR
T1 - Increased expression of platelet-derived growth factor C messenger ribonucleic acid in uterine leiomyomata
AU - Hwu, Yuh Ming
AU - Li, Sheng Hsiang
AU - Lee, Robert Kuo kuang
AU - Tsai, Yu Hui
AU - Tsai, Tian-Shun
AU - Lin, Shyr Yeu
PY - 2008/2
Y1 - 2008/2
N2 - This study was intended to investigate the possible roles of the platelet-derived growth factor (PDGF) gene family's involvement in the pathogenesis of uterine leiomyomata. We examined the differential gene expressions of PDGF-A, -B, -C, -D, PDGF receptor α (PDGFR-α), and receptor β (PDGFR-β) between uterine leiomyomata and the adjacent normal myometrium. Expression of PDGF-C in leiomyomata was significantly higher (approximately 2.4-fold) than in the adjacent normal myometrium, whereas there were no significant differences in the expressions of PDGF-A, -B, -D, PDGFR-α, or PDGFR-β between leiomyomata and the adjacent myometrial tissues.
AB - This study was intended to investigate the possible roles of the platelet-derived growth factor (PDGF) gene family's involvement in the pathogenesis of uterine leiomyomata. We examined the differential gene expressions of PDGF-A, -B, -C, -D, PDGF receptor α (PDGFR-α), and receptor β (PDGFR-β) between uterine leiomyomata and the adjacent normal myometrium. Expression of PDGF-C in leiomyomata was significantly higher (approximately 2.4-fold) than in the adjacent normal myometrium, whereas there were no significant differences in the expressions of PDGF-A, -B, -D, PDGFR-α, or PDGFR-β between leiomyomata and the adjacent myometrial tissues.
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U2 - 10.1016/j.fertnstert.2007.02.031
DO - 10.1016/j.fertnstert.2007.02.031
M3 - Article
C2 - 17482170
AN - SCOPUS:38949146061
SN - 0015-0282
VL - 89
SP - 468
EP - 471
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 2
ER -