Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma

Jia Sin Yang; Mu Kuan Chen; Shun Fa Yang; Yu Chao Chang; Shih Chi Su; Hui Ling Chiou; Ming Hsien Chien; Chiao Wen Lin

doi:10.1515/cclm-2014-0129

Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma

Jia Sin Yang, Mu Kuan Chen, Shun Fa Yang, Yu Chao Chang, Shih Chi Su, Hui Ling Chiou, Ming Hsien Chien, Chiao Wen Lin

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Background: Cumulative evidence has demonstrated that carbonic anhydrase IX (CAIX) is upregulated in many types of human cancers. We attempted to evaluate plasma levels of CAIX in patients with oral cancer and investigated whether plasma CAIX is correlated with the progression of this disease. Method: In total, 191 patients with oral cancer, 30 patients with oral submucous fibrosis and 100 controls were recruited in this study. The plasma samples were collected and the levels of soluble CAIX in plasma were determined by the enzyme-linked immunosorbent assay (ELISA). Furthermore, the normal buccal mucosa fibroblast was challenged by arecoline, the major areca nut alkaloid, to assess the relationship between the levels of CAIX and areca nut chewing in oral cancer patients. Results: Results showed that patients with oral cancer exhibited significantly higher levels of soluble CAIX compared to controls (p

Original language	English
Pages (from-to)	1367-1377
Number of pages	11
Journal	Clinical Chemistry and Laboratory Medicine
Volume	52
Issue number	9
DOIs	https://doi.org/10.1515/cclm-2014-0129
Publication status	Published - Sept 1 2014

Keywords

Carbonic anhydrase IX (CAIX)
Chewed areca nuts
Oral cancer
Oral submucous fibrosis

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical
Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1515/cclm-2014-0129

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title = "Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma",

abstract = "Background: Cumulative evidence has demonstrated that carbonic anhydrase IX (CAIX) is upregulated in many types of human cancers. We attempted to evaluate plasma levels of CAIX in patients with oral cancer and investigated whether plasma CAIX is correlated with the progression of this disease. Method: In total, 191 patients with oral cancer, 30 patients with oral submucous fibrosis and 100 controls were recruited in this study. The plasma samples were collected and the levels of soluble CAIX in plasma were determined by the enzyme-linked immunosorbent assay (ELISA). Furthermore, the normal buccal mucosa fibroblast was challenged by arecoline, the major areca nut alkaloid, to assess the relationship between the levels of CAIX and areca nut chewing in oral cancer patients. Results: Results showed that patients with oral cancer exhibited significantly higher levels of soluble CAIX compared to controls (p",

keywords = "Carbonic anhydrase IX (CAIX), Chewed areca nuts, Oral cancer, Oral submucous fibrosis",

author = "Yang, {Jia Sin} and Chen, {Mu Kuan} and Yang, {Shun Fa} and Chang, {Yu Chao} and Su, {Shih Chi} and Chiou, {Hui Ling} and Chien, {Ming Hsien} and Lin, {Chiao Wen}",

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doi = "10.1515/cclm-2014-0129",

language = "English",

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TY - JOUR

T1 - Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma

AU - Yang, Jia Sin

AU - Chen, Mu Kuan

AU - Yang, Shun Fa

AU - Chang, Yu Chao

AU - Su, Shih Chi

AU - Chiou, Hui Ling

AU - Chien, Ming Hsien

AU - Lin, Chiao Wen

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Background: Cumulative evidence has demonstrated that carbonic anhydrase IX (CAIX) is upregulated in many types of human cancers. We attempted to evaluate plasma levels of CAIX in patients with oral cancer and investigated whether plasma CAIX is correlated with the progression of this disease. Method: In total, 191 patients with oral cancer, 30 patients with oral submucous fibrosis and 100 controls were recruited in this study. The plasma samples were collected and the levels of soluble CAIX in plasma were determined by the enzyme-linked immunosorbent assay (ELISA). Furthermore, the normal buccal mucosa fibroblast was challenged by arecoline, the major areca nut alkaloid, to assess the relationship between the levels of CAIX and areca nut chewing in oral cancer patients. Results: Results showed that patients with oral cancer exhibited significantly higher levels of soluble CAIX compared to controls (p

AB - Background: Cumulative evidence has demonstrated that carbonic anhydrase IX (CAIX) is upregulated in many types of human cancers. We attempted to evaluate plasma levels of CAIX in patients with oral cancer and investigated whether plasma CAIX is correlated with the progression of this disease. Method: In total, 191 patients with oral cancer, 30 patients with oral submucous fibrosis and 100 controls were recruited in this study. The plasma samples were collected and the levels of soluble CAIX in plasma were determined by the enzyme-linked immunosorbent assay (ELISA). Furthermore, the normal buccal mucosa fibroblast was challenged by arecoline, the major areca nut alkaloid, to assess the relationship between the levels of CAIX and areca nut chewing in oral cancer patients. Results: Results showed that patients with oral cancer exhibited significantly higher levels of soluble CAIX compared to controls (p

KW - Carbonic anhydrase IX (CAIX)

KW - Chewed areca nuts

KW - Oral cancer

KW - Oral submucous fibrosis

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Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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