Abstract
Background: Cumulative evidence has demonstrated that carbonic anhydrase IX (CAIX) is upregulated in many types of human cancers. We attempted to evaluate plasma levels of CAIX in patients with oral cancer and investigated whether plasma CAIX is correlated with the progression of this disease. Method: In total, 191 patients with oral cancer, 30 patients with oral submucous fibrosis and 100 controls were recruited in this study. The plasma samples were collected and the levels of soluble CAIX in plasma were determined by the enzyme-linked immunosorbent assay (ELISA). Furthermore, the normal buccal mucosa fibroblast was challenged by arecoline, the major areca nut alkaloid, to assess the relationship between the levels of CAIX and areca nut chewing in oral cancer patients. Results: Results showed that patients with oral cancer exhibited significantly higher levels of soluble CAIX compared to controls (p
Original language | English |
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Pages (from-to) | 1367-1377 |
Number of pages | 11 |
Journal | Clinical Chemistry and Laboratory Medicine |
Volume | 52 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sept 1 2014 |
Keywords
- Carbonic anhydrase IX (CAIX)
- Chewed areca nuts
- Oral cancer
- Oral submucous fibrosis
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical
- Medicine(all)