TY - JOUR
T1 - Increased dietary zinc and vitamin B-2 is associated with increased alanine aminotransferase in Taiwanese adolescents
AU - Bai, Chyi-Huey
AU - Chien, Yi-Wen
AU - Huang, Tzu chieh
AU - Wu, Shin Jiuan
AU - Yeh, Nai Hua
AU - Pan, Harn Wen
AU - Chang, Jung-Su
N1 - Funding Information:
We express our sincere gratitude to all of the study participants. We also thank the staff of the Research Center for Humanities and Social Sciences, Center for Survey Research, Academia Sinica, and Directors Dr Wen-Han Pan and Dr Su-Hao Tu for their valuable support. The data analyzed in this study were obtained from the fourth Nutrition and Health Survey in Taiwan (NAHSIT 2010-11, adolescents), which is a research project sponsored by the Department of Health, Taiwan (DOH94-FS-6-4). Dr Jung-Su Chang received support through grants 103TMU-TMUH-11 and 104TMU-TMUH-18 from Taipei Medical University, and MOST103-2320-B038-015 and MOST104-2311-B038-005 from the Ministry of Science and Technology, Taiwan.
PY - 2017
Y1 - 2017
N2 - Background and Objectives: Alanine aminotransferase (ALT) is generally used for evaluating liver function, and its concentrations are closely associated with sex and nutritional status. This study investigates the relationships between dietary components and serum ALT activity in Taiwanese adolescents. Methods and Study Design: Data were collected from 1,941 adolescents aged 13-18 years who participated in the fourth National Nutrition and Health Survey in Taiwan (2010-2011, adolescents). Results: The mean age was 15.3±0.1 y (15.3±0.1 y for boys and 15.2±0.1 y for girls). Mean serum ALT was 14.8±13.3 U/L (17.7±16.3 U/L for boys and 12.1±8.7 U/L for girls; p < 0.001). Multivariate analysis revealed that, among girls, a single-unit increase in dietary zinc was associated with 1.12- and 1.11-fold increases in risk for increased serum ALT tertile 2 (T2) and T3, respectively, compared with T1; and a single-unit increase in vitamin B-2 intake increased risk by 1.71- and 1.54-fold, respectively. Further analysis revealed that the risk increase for boys and girls who consumed the highest amounts of dietary zinc and vitamin B-2 (T3) was 1.97- and 2.62-fold, respectively; they were also more likely to have higher serum ALT (> 11 U/L for boys and > 9 U/L for girls) than those of the reference (presented as zinc T1 and vitamin B-1 T1). Conclusions: Increased dietary zinc and vitamin B-2 intake is associated with higher serum ALT in adolescents.
AB - Background and Objectives: Alanine aminotransferase (ALT) is generally used for evaluating liver function, and its concentrations are closely associated with sex and nutritional status. This study investigates the relationships between dietary components and serum ALT activity in Taiwanese adolescents. Methods and Study Design: Data were collected from 1,941 adolescents aged 13-18 years who participated in the fourth National Nutrition and Health Survey in Taiwan (2010-2011, adolescents). Results: The mean age was 15.3±0.1 y (15.3±0.1 y for boys and 15.2±0.1 y for girls). Mean serum ALT was 14.8±13.3 U/L (17.7±16.3 U/L for boys and 12.1±8.7 U/L for girls; p < 0.001). Multivariate analysis revealed that, among girls, a single-unit increase in dietary zinc was associated with 1.12- and 1.11-fold increases in risk for increased serum ALT tertile 2 (T2) and T3, respectively, compared with T1; and a single-unit increase in vitamin B-2 intake increased risk by 1.71- and 1.54-fold, respectively. Further analysis revealed that the risk increase for boys and girls who consumed the highest amounts of dietary zinc and vitamin B-2 (T3) was 1.97- and 2.62-fold, respectively; they were also more likely to have higher serum ALT (> 11 U/L for boys and > 9 U/L for girls) than those of the reference (presented as zinc T1 and vitamin B-1 T1). Conclusions: Increased dietary zinc and vitamin B-2 intake is associated with higher serum ALT in adolescents.
KW - Adolescents
KW - Dietary vitamin B-2
KW - Dietary zinc
KW - Hepatic injury
KW - Serum alanine aminotransferase
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U2 - 10.6133/apjcn.102015.09
DO - 10.6133/apjcn.102015.09
M3 - Article
C2 - 28049265
AN - SCOPUS:85010832390
SN - 0964-7058
VL - 26
SP - 78
EP - 84
JO - Asia Pacific Journal of Clinical Nutrition
JF - Asia Pacific Journal of Clinical Nutrition
IS - 1
ER -