Incidental congestive heart failure in patients with aldosterone-producing adenomas

TAIPAI Study Group

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Background-—Previous studies show that patients with primary aldosteronism are associated with higher risk of congestive heart failure (CHF). However, the effect of target treatment to the incidental CHF has not been elucidated. We aimed to investigate the risk of new-onset CHF in patients with aldosterone-producing adenomas (APAs) and explore the effect of adrenalectomy on new onset of CHF. Methods and Results-—From 1997 to 2009, 688 APA were identified and matched with essential hypertension controls. The risks of developing incidental CHF (hazard ratio, 0.49; 95% CI, 0.31–0.75; P=0.001) and mortality (hazard ratio, 0.29; 95% CI, 0.20–0.44; P<0.001) were significantly lower in the APA group after targeted treatment. A total of 605 patients with APAs who underwent adrenalectomy lowered the risks of CHF (subdistribution hazard ratio, 0.55; 95% CI, 0.34–0.90; P=0.017) and mortality (adjusted hazard ratio, 0.27; 95% CI, 0.16–0.44; P<0.001) compared with essential hypertension controls. Conclusions-—In conclusion, for patients with APAs, adrenalectomy can be associated with lower risk of incidental CHF and allcause mortality in a long-term follow-up.

Original languageEnglish
Article numbere012410
JournalJournal of the American Heart Association
Issue number24
Publication statusPublished - Dec 17 2019

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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