TY - JOUR
T1 - Incidence and risk of major adverse cardiovascular events in middle-aged patients with chronic kidney disease
T2 - a population-based cohort study
AU - Chen, Shiauyee
AU - Hsu, Wen yen
AU - Lin, Yen Nung
AU - Wang, Chien Yung
AU - Wu, Chien Hua
AU - Chang, Kwang Hwa
N1 - Funding Information:
This study is based in part on data from the National Health Insurance Research Database provided by the Bureau of National Health Insurance, Department of Health and managed by the National Health Research Institutes. The interpretation and conclusions contained herein do not represent those of the Bureau of National Health Insurance, Department of Health, or National Health Research Institutes. This manuscript was edited by Wallace Academic Editing.
Funding Information:
This study was supported by the Social and Family Affairs Administration, Ministry of Health and Welfare (Grant No. 104037), Taipei, and Wan Fang Hospital, Taipei Medical University (Grant No. 106TMU-WFH-02), Taipei, Taiwan. The funding sources had no role in the study design, collection, analysis or interpretation of the data, writing the manuscript, or the decision to submit the paper for publication.
Publisher Copyright:
© 2019, Springer Nature B.V.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Purpose: For early prevention, information regarding the incidence of major adverse cardiovascular events (MACEs) in middle-aged patients with chronic kidney disease (CKD) may be more beneficial than that regarding MACE prevalence. But, literature comparing the incidence and risk of MACEs in middle-aged patients with CKD with the controls using a population-based cohort study is scant. Our aim was to estimate the incidence and risk of MACEs, such as congestive heart failure (CHF) and ischemic heart disease (IHD), in middle-aged patients with advanced (stages 3–5) CKD. Methods: From the National Health Insurance Research Database, 261 patients aged 35–65 years who had received advanced CKD diagnoses in 2000 and 1305 age-, sex-, and comorbidity-matched controls were recruited. Patients with CHF alone (MACE 1), IHD alone (MACE 2), or CHF and IHD (MACE 3) diagnoses between January 1, 2001, and December 31, 2008, were identified in the CKD and control groups. Results: Patients (mean age ± standard deviation, 50.0 ± 8.3 years; female, 56%) exhibited a higher incidence of MACE 1, MACE 2, and MACE 3 (11.9 vs. 1.4/1000, 30.7 vs. 13.4/1000, and 13.4 vs. 1.7/1000 person-years, respectively, all p < 0.001) and were at a higher risk of experiencing MACEs than the controls (adjusted hazard ratios: MACE 1, MACE 2, and MACE 3: 8.57, 2.26, and 3.80, respectively, all p < 0.001). Conclusions: CKD is an independent risk factor for CHF and IHD among patients aged 35–65 years. Early intervention for preventing CHF and IHD in middle-aged patients with CKD is crucial.
AB - Purpose: For early prevention, information regarding the incidence of major adverse cardiovascular events (MACEs) in middle-aged patients with chronic kidney disease (CKD) may be more beneficial than that regarding MACE prevalence. But, literature comparing the incidence and risk of MACEs in middle-aged patients with CKD with the controls using a population-based cohort study is scant. Our aim was to estimate the incidence and risk of MACEs, such as congestive heart failure (CHF) and ischemic heart disease (IHD), in middle-aged patients with advanced (stages 3–5) CKD. Methods: From the National Health Insurance Research Database, 261 patients aged 35–65 years who had received advanced CKD diagnoses in 2000 and 1305 age-, sex-, and comorbidity-matched controls were recruited. Patients with CHF alone (MACE 1), IHD alone (MACE 2), or CHF and IHD (MACE 3) diagnoses between January 1, 2001, and December 31, 2008, were identified in the CKD and control groups. Results: Patients (mean age ± standard deviation, 50.0 ± 8.3 years; female, 56%) exhibited a higher incidence of MACE 1, MACE 2, and MACE 3 (11.9 vs. 1.4/1000, 30.7 vs. 13.4/1000, and 13.4 vs. 1.7/1000 person-years, respectively, all p < 0.001) and were at a higher risk of experiencing MACEs than the controls (adjusted hazard ratios: MACE 1, MACE 2, and MACE 3: 8.57, 2.26, and 3.80, respectively, all p < 0.001). Conclusions: CKD is an independent risk factor for CHF and IHD among patients aged 35–65 years. Early intervention for preventing CHF and IHD in middle-aged patients with CKD is crucial.
KW - Chronic kidney disease
KW - Congestive heart failure
KW - Incidence
KW - Ischemic heart disease
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U2 - 10.1007/s11255-019-02157-7
DO - 10.1007/s11255-019-02157-7
M3 - Article
AN - SCOPUS:85064818274
SN - 0301-1623
VL - 51
SP - 1219
EP - 1227
JO - International Urology and Nephrology
JF - International Urology and Nephrology
IS - 7
ER -