In vivo graft performance of an improved bone substitute composed of poor crystalline hydroxyapatite based biphasic calcium phosphate

Ching Lien Hung; Jen Chang Yang; Wei Jen Chang; Chih Yuan Hu; Yong Ho Lin; Chun Hsien Huang; Chien Chung Chen; Sheng Yang Lee; Nai Chia Teng

doi:10.4012/dmj.2010-060

In vivo graft performance of an improved bone substitute composed of poor crystalline hydroxyapatite based biphasic calcium phosphate

Ching Lien Hung, Jen Chang Yang, Wei Jen Chang, Chih Yuan Hu, Yong Ho Lin, Chun Hsien Huang, Chien Chung Chen, Sheng Yang Lee, Nai Chia Teng

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The ability to promote new bone formation of poor crystalline hydroxyapatite (PC-HA) based biphasic calcium phosphate (BCP) bone substitutes were investigated. Various ratios of porous PC-HA/β-TCP (70/30, 60/40, and 0/100) grafts were fabricated. SEM and XRD measurements were performed to study the morphology and crystalline structure. Cylindrical artificial bone defects (3×6 mm²) were produced in alveolar bone at premolars extraction site and then filled with sterilized bone grafts. Commercial MBCP® and unfilled empty defect served as control groups. At 8 weeks postoperation, samples were harvested from each artificial defect site for histological analysis. New bone formation of all the PC-HA/β-TCP groups was significantly greater than that of the empty control group (p

Original language	English
Pages (from-to)	21-28
Number of pages	8
Journal	Dental Materials Journal
Volume	30
Issue number	1
DOIs	https://doi.org/10.4012/dmj.2010-060
Publication status	Published - 2011

Keywords

β-tricalcium phosphate
Biphasic calcium phosphate
Bone graft
Hydroxyapatite
In vivo

ASJC Scopus subject areas

Dentistry(all)
Ceramics and Composites

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title = "In vivo graft performance of an improved bone substitute composed of poor crystalline hydroxyapatite based biphasic calcium phosphate",

abstract = "The ability to promote new bone formation of poor crystalline hydroxyapatite (PC-HA) based biphasic calcium phosphate (BCP) bone substitutes were investigated. Various ratios of porous PC-HA/β-TCP (70/30, 60/40, and 0/100) grafts were fabricated. SEM and XRD measurements were performed to study the morphology and crystalline structure. Cylindrical artificial bone defects (3×6 mm2) were produced in alveolar bone at premolars extraction site and then filled with sterilized bone grafts. Commercial MBCP{\textregistered} and unfilled empty defect served as control groups. At 8 weeks postoperation, samples were harvested from each artificial defect site for histological analysis. New bone formation of all the PC-HA/β-TCP groups was significantly greater than that of the empty control group (p",

keywords = "β-tricalcium phosphate, Biphasic calcium phosphate, Bone graft, Hydroxyapatite, In vivo",

author = "Hung, {Ching Lien} and Yang, {Jen Chang} and Chang, {Wei Jen} and Hu, {Chih Yuan} and Lin, {Yong Ho} and Huang, {Chun Hsien} and Chen, {Chien Chung} and Lee, {Sheng Yang} and Teng, {Nai Chia}",

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AU - Hung, Ching Lien

AU - Yang, Jen Chang

AU - Chang, Wei Jen

AU - Hu, Chih Yuan

AU - Lin, Yong Ho

AU - Huang, Chun Hsien

AU - Chen, Chien Chung

AU - Lee, Sheng Yang

AU - Teng, Nai Chia

PY - 2011

Y1 - 2011

N2 - The ability to promote new bone formation of poor crystalline hydroxyapatite (PC-HA) based biphasic calcium phosphate (BCP) bone substitutes were investigated. Various ratios of porous PC-HA/β-TCP (70/30, 60/40, and 0/100) grafts were fabricated. SEM and XRD measurements were performed to study the morphology and crystalline structure. Cylindrical artificial bone defects (3×6 mm2) were produced in alveolar bone at premolars extraction site and then filled with sterilized bone grafts. Commercial MBCP® and unfilled empty defect served as control groups. At 8 weeks postoperation, samples were harvested from each artificial defect site for histological analysis. New bone formation of all the PC-HA/β-TCP groups was significantly greater than that of the empty control group (p

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KW - β-tricalcium phosphate

KW - Biphasic calcium phosphate

KW - Bone graft

KW - Hydroxyapatite

KW - In vivo

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In vivo graft performance of an improved bone substitute composed of poor crystalline hydroxyapatite based biphasic calcium phosphate

Abstract

Keywords

ASJC Scopus subject areas

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