The ability to promote new bone formation of poor crystalline hydroxyapatite (PC-HA) based biphasic calcium phosphate (BCP) bone substitutes were investigated. Various ratios of porous PC-HA/β-TCP (70/30, 60/40, and 0/100) grafts were fabricated. SEM and XRD measurements were performed to study the morphology and crystalline structure. Cylindrical artificial bone defects (3×6 mm2) were produced in alveolar bone at premolars extraction site and then filled with sterilized bone grafts. Commercial MBCP® and unfilled empty defect served as control groups. At 8 weeks postoperation, samples were harvested from each artificial defect site for histological analysis. New bone formation of all the PC-HA/β-TCP groups was significantly greater than that of the empty control group (p

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalDental Materials Journal
Issue number1
Publication statusPublished - 2011


  • β-tricalcium phosphate
  • Biphasic calcium phosphate
  • Bone graft
  • Hydroxyapatite
  • In vivo

ASJC Scopus subject areas

  • Dentistry(all)
  • Ceramics and Composites


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