In vivo evaluation of resorbable bone graft substitutes in mandibular sockets of the beagle

Tsai Chin Shih, Wei Jen Chang, Jen Chang Yang, Sheng-Wei Feng, Che Tong Lin, Nai Chia Teng

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Hydroxyapatite (Ca10(PO4)6(OH) 2), with its high biocompatibility and good bioaffinity, stimulates osteoconduction and is slowly replaced by the host bone after implantation. However, clinical use of HA as a bone substitute has proved problematic. It is difficult to prevent dispersion of the HA granules and to mold the granules into the desired shape. Calcium sulfate as a bone graft substitute is rapidly resorbed in vivo releasing calcium ions, but fails to provide a long-term, three-dimensional framework to support osteoconduction. The setting properties of calcium sulfate, however, allow it to be applied in a slurry form, making it easier to handle and apply in different situations. This study examines the in vivo response of a (Hydroxyapatite, apatitic phase)/calcium sulfate dehydrate (CSD) composite using different ratios in the mandibular premolar sockets of the beagle. The HA (AP)/CSD composite materials prepared in ratios of 30/70, 50/50, and 70/30 were implanted into the mandibular premolar sockets for 5 and 10 weeks. The control socket was empty. The authors compared the radiographic properties and the changes in height and width of the mandibular premolar sockets in the beagle. The composite graft in the 30/70 ratio had the best ability to form new bones.

Original languageEnglish
Pages (from-to)2726-2731
Number of pages6
JournalJournal of Biomedical Materials Research - Part A
Volume100 A
Issue number10
Publication statusPublished - Oct 2012


  • apatitic phase
  • beagle
  • bioaffinity
  • biocompatibility
  • calcium sulfate
  • calcium sulfate dehydrate
  • hydroxyapatite (Ca(PO)(OH) )
  • osteoconduction

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Ceramics and Composites
  • Metals and Alloys


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