In-Vivo Animal Deep Brain Imaging Using Needle-based Optical Coherence Tomography

Tsung Yi Tsai; De Yi Chiou; Chun Chieh Huang; Fu Chiang Jan; Cheng Yi Chang; Shuen Cheng Chen; Yen Chang Wang; Wei Lun Lo; Kai Hsiang Chen; Chun I. Yeh; Yu Ten Ju; Hung Chih Chiang; Chii Wann Lin

doi:10.1117/12.3006576

In-Vivo Animal Deep Brain Imaging Using Needle-based Optical Coherence Tomography

Tsung Yi Tsai, De Yi Chiou, Chun Chieh Huang, Fu Chiang Jan, Cheng Yi Chang, Shuen Cheng Chen, Yen Chang Wang, Wei Lun Lo, Kai Hsiang Chen, Chun I. Yeh, Yu Ten Ju, Hung Chih Chiang, Chii Wann Lin

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Parkinson's disease is a progressive neurodegenerative disease that leads to decreased secretion of nigrostriatal dopamine, which inhibits the activity of the brain's motor cortex, Deep brain stimulation (DBS) is currently the best treatment for patients who do not respond well to drug therapy. The subthalamic nucleus (STN) is the target area for the implanting deep brain electrical stimulation electrodes. Currently, the surgical navigation for DBS depends on pre-operative CT/MRI and intra-operative MER (microelectrode recording) to know whether the electrode has reached the target area, but MER only has non-directional signals. In this project, we developed Optical Coherence Tomography-guided DBS (OCTgDBS) technology, which can obtain real-time, high-resolution images from miniature pig brain, which can assist in the accuracy of navigation and positioning during DBS surgery. Finally, postoperative CT/MRI was used as the basis for positioning in the brain. The results demonstrate that the OCT has a potential to be optical guidance system for DBS.

Original language	English
Title of host publication	Biomedical Imaging and Sensing Conference
Editors	Toyohiko Yatagai
Publisher	SPIE
ISBN (Electronic)	9781510663435
DOIs	https://doi.org/10.1117/12.3006576
Publication status	Published - 2023
Event	Biomedical Imaging and Sensing Conference 2023 - Yokohama, Japan Duration: Apr 17 2023 → Apr 21 2023

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	12608
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Conference

Conference	Biomedical Imaging and Sensing Conference 2023
Country/Territory	Japan
City	Yokohama
Period	4/17/23 → 4/21/23

Keywords

Deep brain simulation
Optical coherence tomography
Parkinson’s disease

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Access to Document

10.1117/12.3006576

Cite this

Tsai, T. Y., Chiou, D. Y., Huang, C. C., Jan, F. C., Chang, C. Y., Chen, S. C., Wang, Y. C., Lo, W. L., Chen, K. H., Yeh, C. I., Ju, Y. T., Chiang, H. C., & Lin, C. W. (2023). In-Vivo Animal Deep Brain Imaging Using Needle-based Optical Coherence Tomography. In T. Yatagai (Ed.), Biomedical Imaging and Sensing Conference Article 1260809 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 12608). SPIE. https://doi.org/10.1117/12.3006576

In-Vivo Animal Deep Brain Imaging Using Needle-based Optical Coherence Tomography. / Tsai, Tsung Yi; Chiou, De Yi; Huang, Chun Chieh et al.
Biomedical Imaging and Sensing Conference. ed. / Toyohiko Yatagai. SPIE, 2023. 1260809 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 12608).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Tsai, TY, Chiou, DY, Huang, CC, Jan, FC, Chang, CY, Chen, SC, Wang, YC, Lo, WL, Chen, KH, Yeh, CI, Ju, YT, Chiang, HC & Lin, CW 2023, In-Vivo Animal Deep Brain Imaging Using Needle-based Optical Coherence Tomography. in T Yatagai (ed.), Biomedical Imaging and Sensing Conference., 1260809, Proceedings of SPIE - The International Society for Optical Engineering, vol. 12608, SPIE, Biomedical Imaging and Sensing Conference 2023, Yokohama, Japan, 4/17/23. https://doi.org/10.1117/12.3006576

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abstract = "Parkinson's disease is a progressive neurodegenerative disease that leads to decreased secretion of nigrostriatal dopamine, which inhibits the activity of the brain's motor cortex, Deep brain stimulation (DBS) is currently the best treatment for patients who do not respond well to drug therapy. The subthalamic nucleus (STN) is the target area for the implanting deep brain electrical stimulation electrodes. Currently, the surgical navigation for DBS depends on pre-operative CT/MRI and intra-operative MER (microelectrode recording) to know whether the electrode has reached the target area, but MER only has non-directional signals. In this project, we developed Optical Coherence Tomography-guided DBS (OCTgDBS) technology, which can obtain real-time, high-resolution images from miniature pig brain, which can assist in the accuracy of navigation and positioning during DBS surgery. Finally, postoperative CT/MRI was used as the basis for positioning in the brain. The results demonstrate that the OCT has a potential to be optical guidance system for DBS.",

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AB - Parkinson's disease is a progressive neurodegenerative disease that leads to decreased secretion of nigrostriatal dopamine, which inhibits the activity of the brain's motor cortex, Deep brain stimulation (DBS) is currently the best treatment for patients who do not respond well to drug therapy. The subthalamic nucleus (STN) is the target area for the implanting deep brain electrical stimulation electrodes. Currently, the surgical navigation for DBS depends on pre-operative CT/MRI and intra-operative MER (microelectrode recording) to know whether the electrode has reached the target area, but MER only has non-directional signals. In this project, we developed Optical Coherence Tomography-guided DBS (OCTgDBS) technology, which can obtain real-time, high-resolution images from miniature pig brain, which can assist in the accuracy of navigation and positioning during DBS surgery. Finally, postoperative CT/MRI was used as the basis for positioning in the brain. The results demonstrate that the OCT has a potential to be optical guidance system for DBS.

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In-Vivo Animal Deep Brain Imaging Using Needle-based Optical Coherence Tomography

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

Access to Document

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