In-Vitro Tumor and Microenvironment Reconstruction Labchip Applied to HIPEC Drug Screening

Jing Wen Guo, Chin Yung Hsu, Zhi Yin Chao, Mao Chih Hsieh, Yu Ting Tai, Hwan You Chan, Si Jin Dong, Cheng Hsien Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present a tumor-culturing microfluidic chip that combines 3D cell spheroids culturing and drug screening; The microfluidic chip takes advantage of specific flow channels and microwells to generate three kinds of co-cultured cell spheroids with varying ratios of cells. The drug combination will flow into spheroid culture areas to treat tumor spheroids. The in-vivo actual situation is approached through our design of the in-vitro tumor and microenvironment. This microfluidic chip is aimed to provide a tumor microenvironment reconstruction and drug screening platform, which become a reference for doctors' drug combination treatment.

Original languageEnglish
Title of host publication2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages939-942
Number of pages4
ISBN (Electronic)9784886864352
Publication statusPublished - 2023
Event22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023 - Kyoto, Japan
Duration: Jun 25 2023Jun 29 2023

Publication series

Name2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023

Conference

Conference22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023
Country/TerritoryJapan
CityKyoto
Period6/25/236/29/23

Keywords

  • Drug testing platform
  • Hyperthermic Intraperitoneal Chemotherapy
  • Microfluidics chip
  • Multicellular tumor spheroids
  • Peritoneal carcinomatosis

ASJC Scopus subject areas

  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Control and Optimization
  • Instrumentation

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