In vitro cell study of possible anti-inflammatory and pain relief mechanism of far-infrared ray-emitting ceramic material

Ting-Kai Leung; Yu Chuan Liu; Chien Ho Chen; Hsieh Nien-Fang; Kun Cho Chen; Chi-Ming Lee

doi:10.5405/jmbe.1029

In vitro cell study of possible anti-inflammatory and pain relief mechanism of far-infrared ray-emitting ceramic material

Ting-Kai Leung, Yu Chuan Liu, Chien Ho Chen, Hsieh Nien-Fang, Kun Cho Chen, Chi-Ming Lee

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Inflammation and pain are the major chronic symptoms in geriatric medicine. This study examines the possible mechanism of a far-infrared ray-emitting ceramic material (bioceramic) on these symptoms using cell models. Effective doses of lipopolysaccharides (LPS) were added to induce acute episodes of inflammation in murine macrophage (RAW 264.7) and human chondrosarcoma (SW1353) cells. The inducible nitric oxide synthetase (iNOS), cyclo-oxygenase-2 (COX-2), and prostaglandin E2 (PGE2) levels were determined for the cell lines. Biocermic treatment was found to have significant inhibitory effects on COX-2 and PGE2 and a probable effect on iNOS in the cell models of LPS-mediated inflammation. Bioceramic treatment may be an alternative method for palliative pain control to reduce chemical drug dependence for the protection of renal functions in the chronic pain disease population.

Original language	English
Pages (from-to)	179-184
Number of pages	6
Journal	Journal of Medical and Biological Engineering
Volume	33
Issue number	2
DOIs	https://doi.org/10.5405/jmbe.1029
Publication status	Published - 2013

Keywords

Bone marrow stromal cells (BMSCs)
Collagen I nanospheres
Osteogenic differentiation

ASJC Scopus subject areas

Biomedical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5405/jmbe.1029

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title = "In vitro cell study of possible anti-inflammatory and pain relief mechanism of far-infrared ray-emitting ceramic material",

abstract = "Inflammation and pain are the major chronic symptoms in geriatric medicine. This study examines the possible mechanism of a far-infrared ray-emitting ceramic material (bioceramic) on these symptoms using cell models. Effective doses of lipopolysaccharides (LPS) were added to induce acute episodes of inflammation in murine macrophage (RAW 264.7) and human chondrosarcoma (SW1353) cells. The inducible nitric oxide synthetase (iNOS), cyclo-oxygenase-2 (COX-2), and prostaglandin E2 (PGE2) levels were determined for the cell lines. Biocermic treatment was found to have significant inhibitory effects on COX-2 and PGE2 and a probable effect on iNOS in the cell models of LPS-mediated inflammation. Bioceramic treatment may be an alternative method for palliative pain control to reduce chemical drug dependence for the protection of renal functions in the chronic pain disease population.",

keywords = "Bone marrow stromal cells (BMSCs), Collagen I nanospheres, Osteogenic differentiation",

author = "Ting-Kai Leung and Liu, {Yu Chuan} and Chen, {Chien Ho} and Hsieh Nien-Fang and Chen, {Kun Cho} and Chi-Ming Lee",

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AU - Leung, Ting-Kai

AU - Liu, Yu Chuan

AU - Chen, Chien Ho

AU - Nien-Fang, Hsieh

AU - Chen, Kun Cho

AU - Lee, Chi-Ming

PY - 2013

Y1 - 2013

N2 - Inflammation and pain are the major chronic symptoms in geriatric medicine. This study examines the possible mechanism of a far-infrared ray-emitting ceramic material (bioceramic) on these symptoms using cell models. Effective doses of lipopolysaccharides (LPS) were added to induce acute episodes of inflammation in murine macrophage (RAW 264.7) and human chondrosarcoma (SW1353) cells. The inducible nitric oxide synthetase (iNOS), cyclo-oxygenase-2 (COX-2), and prostaglandin E2 (PGE2) levels were determined for the cell lines. Biocermic treatment was found to have significant inhibitory effects on COX-2 and PGE2 and a probable effect on iNOS in the cell models of LPS-mediated inflammation. Bioceramic treatment may be an alternative method for palliative pain control to reduce chemical drug dependence for the protection of renal functions in the chronic pain disease population.

AB - Inflammation and pain are the major chronic symptoms in geriatric medicine. This study examines the possible mechanism of a far-infrared ray-emitting ceramic material (bioceramic) on these symptoms using cell models. Effective doses of lipopolysaccharides (LPS) were added to induce acute episodes of inflammation in murine macrophage (RAW 264.7) and human chondrosarcoma (SW1353) cells. The inducible nitric oxide synthetase (iNOS), cyclo-oxygenase-2 (COX-2), and prostaglandin E2 (PGE2) levels were determined for the cell lines. Biocermic treatment was found to have significant inhibitory effects on COX-2 and PGE2 and a probable effect on iNOS in the cell models of LPS-mediated inflammation. Bioceramic treatment may be an alternative method for palliative pain control to reduce chemical drug dependence for the protection of renal functions in the chronic pain disease population.

KW - Bone marrow stromal cells (BMSCs)

KW - Collagen I nanospheres

KW - Osteogenic differentiation

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In vitro cell study of possible anti-inflammatory and pain relief mechanism of far-infrared ray-emitting ceramic material

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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