In situ detection of Epstein-Barr virus in breast cancer

Jan Show Chu; Chung Chung Chen; King Jen Chang

doi:10.1016/S0304-3835(97)00449-7

In situ detection of Epstein-Barr virus in breast cancer

Jan Show Chu, Chung Chung Chen, King Jen Chang

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV) is strongly associated with nasopharyngeal carcinoma and some lymphoepithelioma-like carcinomas from other anatomic sites. This study investigates the presence of EBV in breast cancer. Immunohistochemistry for EBV proteins (EBV nuclear antigen-2 and latent membrane protein-1) and in situ hybridization for EBV-encoded small nuclear RNAs (EBER-1 and -2) were performed in 60 invasive breast cancers. None of the 60 breast cancer samples showed detectable EBV. These results suggest that EBV may not play a significant role in the etiology of breast cancers in Taiwan.

Original language	English
Pages (from-to)	53-57
Number of pages	5
Journal	Cancer Letters
Volume	124
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(97)00449-7
Publication status	Published - Feb 13 1998
Externally published	Yes

Keywords

Breast cancer
Epstein-Barr virus
Immunohistochemistry
In situ hybridization

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(97)00449-7

Cite this

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title = "In situ detection of Epstein-Barr virus in breast cancer",

abstract = "Epstein-Barr virus (EBV) is strongly associated with nasopharyngeal carcinoma and some lymphoepithelioma-like carcinomas from other anatomic sites. This study investigates the presence of EBV in breast cancer. Immunohistochemistry for EBV proteins (EBV nuclear antigen-2 and latent membrane protein-1) and in situ hybridization for EBV-encoded small nuclear RNAs (EBER-1 and -2) were performed in 60 invasive breast cancers. None of the 60 breast cancer samples showed detectable EBV. These results suggest that EBV may not play a significant role in the etiology of breast cancers in Taiwan.",

keywords = "Breast cancer, Epstein-Barr virus, Immunohistochemistry, In situ hybridization",

author = "Chu, {Jan Show} and Chen, {Chung Chung} and Chang, {King Jen}",

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doi = "10.1016/S0304-3835(97)00449-7",

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T1 - In situ detection of Epstein-Barr virus in breast cancer

AU - Chu, Jan Show

AU - Chen, Chung Chung

AU - Chang, King Jen

PY - 1998/2/13

Y1 - 1998/2/13

N2 - Epstein-Barr virus (EBV) is strongly associated with nasopharyngeal carcinoma and some lymphoepithelioma-like carcinomas from other anatomic sites. This study investigates the presence of EBV in breast cancer. Immunohistochemistry for EBV proteins (EBV nuclear antigen-2 and latent membrane protein-1) and in situ hybridization for EBV-encoded small nuclear RNAs (EBER-1 and -2) were performed in 60 invasive breast cancers. None of the 60 breast cancer samples showed detectable EBV. These results suggest that EBV may not play a significant role in the etiology of breast cancers in Taiwan.

AB - Epstein-Barr virus (EBV) is strongly associated with nasopharyngeal carcinoma and some lymphoepithelioma-like carcinomas from other anatomic sites. This study investigates the presence of EBV in breast cancer. Immunohistochemistry for EBV proteins (EBV nuclear antigen-2 and latent membrane protein-1) and in situ hybridization for EBV-encoded small nuclear RNAs (EBER-1 and -2) were performed in 60 invasive breast cancers. None of the 60 breast cancer samples showed detectable EBV. These results suggest that EBV may not play a significant role in the etiology of breast cancers in Taiwan.

KW - Breast cancer

KW - Epstein-Barr virus

KW - Immunohistochemistry

KW - In situ hybridization

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DO - 10.1016/S0304-3835(97)00449-7

M3 - Article

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SN - 0304-3835

VL - 124

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EP - 57

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

In situ detection of Epstein-Barr virus in breast cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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