TY - JOUR
T1 - Improving the safety of tolerance induction
T2 - Chimerism and cellular co-treatment strategies applied to vascularized composite allografts
AU - Huang, Wei Chao
AU - Lin, Jeng Yee
AU - Wallace, Christopher Glenn
AU - Wei, Fu Chan
AU - Liao, Shuen Kuei
PY - 2012
Y1 - 2012
N2 - Although vascularized composite allografts (VCAs) have been performed clinically for a variety of indications, potential complications from long-term immunosuppression and graft-versus-host disease remain important barriers to widespread applications. Recently it has been demonstrated that VCAs incorporating a vascularized long bone in a rat model provide concurrent vascularized bone marrow transplantation that, itself, functions to establish hematopoietic chimerism and donor-specific tolerance following non-myeloablative conditioning of recipients. Advances such as this, which aim to improve the safety profile of tolerance induction, will help usher in an era of wider clinical VCA application for nonlife-saving reconstructions.
AB - Although vascularized composite allografts (VCAs) have been performed clinically for a variety of indications, potential complications from long-term immunosuppression and graft-versus-host disease remain important barriers to widespread applications. Recently it has been demonstrated that VCAs incorporating a vascularized long bone in a rat model provide concurrent vascularized bone marrow transplantation that, itself, functions to establish hematopoietic chimerism and donor-specific tolerance following non-myeloablative conditioning of recipients. Advances such as this, which aim to improve the safety profile of tolerance induction, will help usher in an era of wider clinical VCA application for nonlife-saving reconstructions.
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U2 - 10.1155/2012/107901
DO - 10.1155/2012/107901
M3 - Review article
C2 - 23118778
AN - SCOPUS:84868682900
SN - 1740-2522
VL - 2012
JO - Clinical and Developmental Immunology
JF - Clinical and Developmental Immunology
M1 - 107901
ER -