Importance of dual delivery systems for bone tissue engineering

Mehdi Farokhi; Fatemeh Mottaghitalab; Mohammad Ali Shokrgozar; Keng Liang Ou; Chuanbin Mao; Hossein Hosseinkhani

doi:10.1016/j.jconrel.2016.01.033

Importance of dual delivery systems for bone tissue engineering

Mehdi Farokhi, Fatemeh Mottaghitalab, Mohammad Ali Shokrgozar, Keng Liang Ou, Chuanbin Mao, Hossein Hosseinkhani

Research output: Contribution to journal › Review article › peer-review

152 Citations (Scopus)

Abstract

Bone formation is a complex process that requires concerted function of multiple growth factors. For this, it is essential to design a delivery system with the ability to load multiple growth factors in order to mimic the natural microenvironment for bone tissue formation. However, the short half-lives of growth factors, their relatively large size, slow tissue penetration, and high toxicity suggest that conventional routes of administration are unlikely to be effective. Therefore, it seems that using multiple bioactive factors in different delivery systems can develop new strategies for improving bone tissue regeneration. Combination of these factors along with biomaterials that permit tunable release profiles would help to achieve truly spatiotemporal regulation during delivery. This review summarizes the various dual-control release systems that are used for bone tissue engineering.

Original language	English
Pages (from-to)	152-169
Number of pages	18
Journal	Journal of Controlled Release
Volume	225
DOIs	https://doi.org/10.1016/j.jconrel.2016.01.033
Publication status	Published - Mar 10 2016

Keywords

Bone regeneration
Dual drug delivery
Tissue engineering

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.jconrel.2016.01.033

Cite this

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title = "Importance of dual delivery systems for bone tissue engineering",

abstract = "Bone formation is a complex process that requires concerted function of multiple growth factors. For this, it is essential to design a delivery system with the ability to load multiple growth factors in order to mimic the natural microenvironment for bone tissue formation. However, the short half-lives of growth factors, their relatively large size, slow tissue penetration, and high toxicity suggest that conventional routes of administration are unlikely to be effective. Therefore, it seems that using multiple bioactive factors in different delivery systems can develop new strategies for improving bone tissue regeneration. Combination of these factors along with biomaterials that permit tunable release profiles would help to achieve truly spatiotemporal regulation during delivery. This review summarizes the various dual-control release systems that are used for bone tissue engineering.",

keywords = "Bone regeneration, Dual drug delivery, Tissue engineering",

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AU - Farokhi, Mehdi

AU - Mottaghitalab, Fatemeh

AU - Shokrgozar, Mohammad Ali

AU - Ou, Keng Liang

AU - Mao, Chuanbin

AU - Hosseinkhani, Hossein

PY - 2016/3/10

Y1 - 2016/3/10

N2 - Bone formation is a complex process that requires concerted function of multiple growth factors. For this, it is essential to design a delivery system with the ability to load multiple growth factors in order to mimic the natural microenvironment for bone tissue formation. However, the short half-lives of growth factors, their relatively large size, slow tissue penetration, and high toxicity suggest that conventional routes of administration are unlikely to be effective. Therefore, it seems that using multiple bioactive factors in different delivery systems can develop new strategies for improving bone tissue regeneration. Combination of these factors along with biomaterials that permit tunable release profiles would help to achieve truly spatiotemporal regulation during delivery. This review summarizes the various dual-control release systems that are used for bone tissue engineering.

AB - Bone formation is a complex process that requires concerted function of multiple growth factors. For this, it is essential to design a delivery system with the ability to load multiple growth factors in order to mimic the natural microenvironment for bone tissue formation. However, the short half-lives of growth factors, their relatively large size, slow tissue penetration, and high toxicity suggest that conventional routes of administration are unlikely to be effective. Therefore, it seems that using multiple bioactive factors in different delivery systems can develop new strategies for improving bone tissue regeneration. Combination of these factors along with biomaterials that permit tunable release profiles would help to achieve truly spatiotemporal regulation during delivery. This review summarizes the various dual-control release systems that are used for bone tissue engineering.

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Importance of dual delivery systems for bone tissue engineering

Abstract

Keywords

ASJC Scopus subject areas

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