Importance of dual delivery systems for bone tissue engineering

Mehdi Farokhi, Fatemeh Mottaghitalab, Mohammad Ali Shokrgozar, Keng Liang Ou, Chuanbin Mao, Hossein Hosseinkhani

Research output: Contribution to journalArticlepeer-review

141 Citations (Scopus)


Bone formation is a complex process that requires concerted function of multiple growth factors. For this, it is essential to design a delivery system with the ability to load multiple growth factors in order to mimic the natural microenvironment for bone tissue formation. However, the short half-lives of growth factors, their relatively large size, slow tissue penetration, and high toxicity suggest that conventional routes of administration are unlikely to be effective. Therefore, it seems that using multiple bioactive factors in different delivery systems can develop new strategies for improving bone tissue regeneration. Combination of these factors along with biomaterials that permit tunable release profiles would help to achieve truly spatiotemporal regulation during delivery. This review summarizes the various dual-control release systems that are used for bone tissue engineering.

Original languageEnglish
Pages (from-to)152-169
Number of pages18
JournalJournal of Controlled Release
Publication statusPublished - Mar 10 2016


  • Bone regeneration
  • Dual drug delivery
  • Tissue engineering

ASJC Scopus subject areas

  • Pharmaceutical Science


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