TY - JOUR
T1 - Impaired self-referential processing in mesial temporal lobe epilepsy
T2 - A functional MRI study
AU - Yuan, Cuiping
AU - Zhang, Zhiqiang
AU - Wang, Zhengge
AU - Liao, Wei
AU - Chen, Guanghui
AU - Northoff, Georg
AU - Lu, Guangming
N1 - Funding Information:
This research was supported by the Natural Science Foundation of China (Grant nos. 81271553 , 81301198 , 81201155 , 81201178 , and 81020108022 ), Grants for Young Scholar of Jinling Hospital (Grant nos. 2011060 and 2011045 ).
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013/10/25
Y1 - 2013/10/25
N2 - Mesial temporal lobe epilepsy (mTLE) presents typical symptoms of cognitive impairments and mental disorders, which is presumed to be related to impairment of self-referential processing. This study aims to investigate the alterations of self-reference in mTLE using functional magnetic resonance imaging (fMRI). Fifty patients with unilateral mTLE (26 left- and 24 right-sided mTLE) were recruited in the present study. Traditional task paradigm of internally-cued condition vs. externally-cued condition was employed to induce self-referential activation. FMRI activation in each group of patients was compared with that of 30 healthy controls. Moreover, fMRI responses in the dorsal mesial prefrontal cortex were specifically addressed by correlating with behavioral data of reaction times and clinical data of epilepsy duration, respectively. Compared with the healthy controls, both two groups of patients showed decreased behavioral performance (reaction times) and decreased fMRI activation of self-reference in the anterior and posterior cortical midline structures. Moreover, fMRI activation was found to be negatively correlated with behavioral performance and epilepsy duration. The present findings implicate functional impairment of self-reference caused by epilepsy in mTLE. This study provided imaging evidence for functional impairments of self-referential processing and brain default-mode function in mTLE.
AB - Mesial temporal lobe epilepsy (mTLE) presents typical symptoms of cognitive impairments and mental disorders, which is presumed to be related to impairment of self-referential processing. This study aims to investigate the alterations of self-reference in mTLE using functional magnetic resonance imaging (fMRI). Fifty patients with unilateral mTLE (26 left- and 24 right-sided mTLE) were recruited in the present study. Traditional task paradigm of internally-cued condition vs. externally-cued condition was employed to induce self-referential activation. FMRI activation in each group of patients was compared with that of 30 healthy controls. Moreover, fMRI responses in the dorsal mesial prefrontal cortex were specifically addressed by correlating with behavioral data of reaction times and clinical data of epilepsy duration, respectively. Compared with the healthy controls, both two groups of patients showed decreased behavioral performance (reaction times) and decreased fMRI activation of self-reference in the anterior and posterior cortical midline structures. Moreover, fMRI activation was found to be negatively correlated with behavioral performance and epilepsy duration. The present findings implicate functional impairment of self-reference caused by epilepsy in mTLE. This study provided imaging evidence for functional impairments of self-referential processing and brain default-mode function in mTLE.
KW - FMRI.
KW - Mesial temporal lobe epilepsy
KW - Self-reference
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U2 - 10.1016/j.neulet.2013.09.054
DO - 10.1016/j.neulet.2013.09.054
M3 - Article
C2 - 24090819
AN - SCOPUS:84885767545
SN - 0304-3940
VL - 555
SP - 187
EP - 192
JO - Neuroscience Letters
JF - Neuroscience Letters
ER -