Impaired glucose tolerance and impaired fasting glucose share similar underlying pathophysiologies

Jiunn Diann Lin, Hsiang Lin Wan, Jer Chuan Li, Chung Ze Wu, Shi Wen Kuo, Chang Hsun Hsieh, Wei Chen Lian, Chien Hsing Lee, Mei Teng Kao, Dee Pei

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Both impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) are pre-diabetic states. IGT was defined as having normal fasting plasma glucose (< 6.1 mmol/1) and abnormal 2-hr post-challenge plasma glucose. IFG was defined as having abnormal fasting plasma and normal 2-hr post-challenge plasma glucose (< 7.8 mmol/1). To explore whether these two abnormalities share similar underlying pathophysiologies, we evaluated risk factors of IGT and IFT using the models of factor analysis. The present study included 107 subjects with IGT and 52 with IFG. An oral glucose tolerance test and insulin suppression test, which could quantify insulin resistance, were performed on separate days. The risk factors include waist-to-hip ratio (WHR), triglycerides, high-density lipoprotein (HDL)-cholesterol, blood pressure, and fasting plasma glucose, which are associated with metabolic syndrome and insulin resistance. Factor analysis is a commonly used statistical method that could reduce a large number of risk factors into smaller numbers of groups, also called dimension. Accordingly, the complicated data could be interpreted more easily, since the related risk factors are grouped in one dimension. The results showed that the risk factors of IGT and IFG have similar grouping patterns. Triglyceride, insulin resistance, and HDL-cholesterol were grouped in one dimension (the lipid dimension), while WHR, mean blood pressure and fasting plasma glucose were grouped in another dimension (the metabolic dimension). In conclusion; except for WHR, the grouping patterns of the components in both IGT and IFG were nearly identical. These results suggest that IGT and IFG may share similar pathophysiologies.

Original languageEnglish
Pages (from-to)349-357
Number of pages9
JournalTohoku Journal of Experimental Medicine
Issue number4
Publication statusPublished - Jul 27 2007
Externally publishedYes


  • Factor analysis
  • Impaired fasting glucose
  • Impaired glucose tolerance
  • Insulin resistance
  • Metabolic syndrome

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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