TY - JOUR
T1 - Impact of traumatic brain injury on dopaminergic transmission
AU - Chen, Yuan Hao
AU - Huang, Eagle Yi Kung
AU - Kuo, Tung Tai
AU - Miller, Jonathan
AU - Chiang, Yung Hsiao
AU - Hoffer, Barry J.
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research and/or authorship of this article: This work was supported by the National Science Council of Taiwan under grant NSC102-2314-B-016-030*MY3, NSC 105-2314-B-016-001-MY3, and by Medical Research Project grants TSGH-C105-075, TSGH-C103-083, TSGH-C104-187 from the Tri-Service General Hospital of Taiwan and MAB-105-105 from National Defense Medical Center. This project was also supported in part by philanthropic support from the George R. and Constance P. Lincoln family.
Publisher Copyright:
© The Author(s) 2017.
PY - 2017/7
Y1 - 2017/7
N2 - Brain trauma is often associated with severe morbidity and is a major public health concern. Even when injury is mild and no obvious anatomic disruption is seen, many individuals suffer disabling neuropsychological impairments such as memory loss, mood dysfunction, substance abuse, and adjustment disorder. These changes may be related to subtle disruption of neural circuits as well as functional changes at the neurotransmitter level. In particular, there is considerable evidence that dopamine (DA) physiology in the nigrostriatal and mesocorticolimbic pathways might be impaired after traumatic brain injury (TBI). Alterations in DA levels can lead to oxidative stress and cellular dysfunction, and DA plays an important role in central nervous system inflammation. Therapeutic targeting of DA pathways may offer benefits for both neuronal survival and functional outcome after TBI. The purpose of this review is to discuss the role of DA pathology in acute TBI and the potential impact of therapies that target these systems for the treatment of TBI.
AB - Brain trauma is often associated with severe morbidity and is a major public health concern. Even when injury is mild and no obvious anatomic disruption is seen, many individuals suffer disabling neuropsychological impairments such as memory loss, mood dysfunction, substance abuse, and adjustment disorder. These changes may be related to subtle disruption of neural circuits as well as functional changes at the neurotransmitter level. In particular, there is considerable evidence that dopamine (DA) physiology in the nigrostriatal and mesocorticolimbic pathways might be impaired after traumatic brain injury (TBI). Alterations in DA levels can lead to oxidative stress and cellular dysfunction, and DA plays an important role in central nervous system inflammation. Therapeutic targeting of DA pathways may offer benefits for both neuronal survival and functional outcome after TBI. The purpose of this review is to discuss the role of DA pathology in acute TBI and the potential impact of therapies that target these systems for the treatment of TBI.
KW - DA
KW - Traumatic brain injury
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U2 - 10.1177/0963689717714105
DO - 10.1177/0963689717714105
M3 - Review article
AN - SCOPUS:85032024091
SN - 0963-6897
VL - 26
SP - 1156
EP - 1168
JO - Cell Transplantation
JF - Cell Transplantation
IS - 7
ER -
