Immunosuppressive roles of galectin-1 in the tumor microenvironment

Yanyu Huang; Hsiao Chi Wang; Junwei Zhao; Ming Heng Wu; Tsung Chieh Shih

doi:10.3390/biom11101398

Immunosuppressive roles of galectin-1 in the tumor microenvironment

Yanyu Huang
, Hsiao Chi Wang
, Junwei Zhao
, Ming Heng Wu
, Tsung Chieh Shih

Research output: Contribution to journal › Review article › peer-review

57 Citations (Scopus)

Abstract

Evasion of immune surveillance is an accepted hallmark of tumor progression. The production of immune suppressive mediators by tumor cells is one of the major mechanisms of tumor immune escape. Galectin-1 (Gal-1), a pivotal immunosuppressive molecule, is expressed by many types of cancer. Tumor-secreted Gal-1 can bind to glycosylated receptors on immune cells and trigger the suppression of immune cell function in the tumor microenvironment, contributing to the immune evasion of tumors. The aim of this review is to summarize the current literature on the expression and function of Gal-1 in the human tumor microenvironment, as well as therapeutics targeting Gal-1.

Original language	English
Article number	1398
Journal	Biomolecules
Volume	11
Issue number	10
DOIs	https://doi.org/10.3390/biom11101398
Publication status	Published - Oct 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Galectin-1
Immunotherapy
LLS30
Microenvironment

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.3390/biom11101398

Cite this

@article{412517433ed94d249bab264b5fdfe1a1,

title = "Immunosuppressive roles of galectin-1 in the tumor microenvironment",

abstract = "Evasion of immune surveillance is an accepted hallmark of tumor progression. The production of immune suppressive mediators by tumor cells is one of the major mechanisms of tumor immune escape. Galectin-1 (Gal-1), a pivotal immunosuppressive molecule, is expressed by many types of cancer. Tumor-secreted Gal-1 can bind to glycosylated receptors on immune cells and trigger the suppression of immune cell function in the tumor microenvironment, contributing to the immune evasion of tumors. The aim of this review is to summarize the current literature on the expression and function of Gal-1 in the human tumor microenvironment, as well as therapeutics targeting Gal-1.",

keywords = "Galectin-1, Immunotherapy, LLS30, Microenvironment",

author = "Yanyu Huang and Wang, \{Hsiao Chi\} and Junwei Zhao and Wu, \{Ming Heng\} and Shih, \{Tsung Chieh\}",

note = "Funding Information: Funding: This study is supported by grants funded by the Department of Defense Prostate Cancer Research Program W81XWH-19-1-0532 to Shih and the University of California Davis Comprehensive Cancer Center seed grants to Shih. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = oct,

doi = "10.3390/biom11101398",

language = "English",

volume = "11",

journal = "Biomolecules",

issn = "2218-273X",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "10",

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TY - JOUR

T1 - Immunosuppressive roles of galectin-1 in the tumor microenvironment

AU - Huang, Yanyu

AU - Wang, Hsiao Chi

AU - Zhao, Junwei

AU - Wu, Ming Heng

AU - Shih, Tsung Chieh

N1 - Funding Information: Funding: This study is supported by grants funded by the Department of Defense Prostate Cancer Research Program W81XWH-19-1-0532 to Shih and the University of California Davis Comprehensive Cancer Center seed grants to Shih. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/10

Y1 - 2021/10

N2 - Evasion of immune surveillance is an accepted hallmark of tumor progression. The production of immune suppressive mediators by tumor cells is one of the major mechanisms of tumor immune escape. Galectin-1 (Gal-1), a pivotal immunosuppressive molecule, is expressed by many types of cancer. Tumor-secreted Gal-1 can bind to glycosylated receptors on immune cells and trigger the suppression of immune cell function in the tumor microenvironment, contributing to the immune evasion of tumors. The aim of this review is to summarize the current literature on the expression and function of Gal-1 in the human tumor microenvironment, as well as therapeutics targeting Gal-1.

AB - Evasion of immune surveillance is an accepted hallmark of tumor progression. The production of immune suppressive mediators by tumor cells is one of the major mechanisms of tumor immune escape. Galectin-1 (Gal-1), a pivotal immunosuppressive molecule, is expressed by many types of cancer. Tumor-secreted Gal-1 can bind to glycosylated receptors on immune cells and trigger the suppression of immune cell function in the tumor microenvironment, contributing to the immune evasion of tumors. The aim of this review is to summarize the current literature on the expression and function of Gal-1 in the human tumor microenvironment, as well as therapeutics targeting Gal-1.

KW - Galectin-1

KW - Immunotherapy

KW - LLS30

KW - Microenvironment

UR - https://www.scopus.com/pages/publications/85115361975

UR - https://www.scopus.com/pages/publications/85115361975#tab=citedBy

U2 - 10.3390/biom11101398

DO - 10.3390/biom11101398

M3 - Review article

AN - SCOPUS:85115361975

SN - 2218-273X

VL - 11

JO - Biomolecules

JF - Biomolecules

IS - 10

M1 - 1398

ER -

Immunosuppressive roles of galectin-1 in the tumor microenvironment

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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