Immunopathology of hepatitis B virus infection

Hsiu Ting Tsai; Tzu Hsin Tsai; Tsong Ming Lu; Chi Chiang Yang

doi:10.1080/08830180802295757

Immunopathology of hepatitis B virus infection

Hsiu Ting Tsai, Tzu Hsin Tsai, Tsong Ming Lu, Chi Chiang Yang

Research output: Contribution to journal › Review article › peer-review

19 Citations (Scopus)

Abstract

The interaction between immune responses and hepatitis B virus (HBV) is coordinated between innate and adaptive immunity. Anti-HBs antibodies protect the host by blocking the binding ability of HBV. Anti-HBc antibodies are detected with persistent HBV infection. The presence of anti-HBe antibodies is often associated with recovery from active diseases and is clinically used as a benchmark to assess response to treatment. Our studies have revealed that the anti-HBV immunoglobulins secreted are different in subclass patterns in different HBV infection status populations. These revelations may help to understand HBV escape and persistent infection and to develop strategies for prevention and therapeutic management of HBV infection.

Original language	English
Pages (from-to)	427-446
Number of pages	20
Journal	International Reviews of Immunology
Volume	27
Issue number	6
DOIs	https://doi.org/10.1080/08830180802295757
Publication status	Published - Nov 2008
Externally published	Yes

Keywords

Cellular immunity
Hepatitis B virus
Humoral immunity
IgG subclass
Immunopathology
Regulatory T cell

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/08830180802295757

Cite this

@article{37416be19a314491af7368edd023b2d0,

title = "Immunopathology of hepatitis B virus infection",

abstract = "The interaction between immune responses and hepatitis B virus (HBV) is coordinated between innate and adaptive immunity. Anti-HBs antibodies protect the host by blocking the binding ability of HBV. Anti-HBc antibodies are detected with persistent HBV infection. The presence of anti-HBe antibodies is often associated with recovery from active diseases and is clinically used as a benchmark to assess response to treatment. Our studies have revealed that the anti-HBV immunoglobulins secreted are different in subclass patterns in different HBV infection status populations. These revelations may help to understand HBV escape and persistent infection and to develop strategies for prevention and therapeutic management of HBV infection.",

keywords = "Cellular immunity, Hepatitis B virus, Humoral immunity, IgG subclass, Immunopathology, Regulatory T cell",

author = "Tsai, {Hsiu Ting} and Tsai, {Tzu Hsin} and Lu, {Tsong Ming} and Yang, {Chi Chiang}",

year = "2008",

month = nov,

doi = "10.1080/08830180802295757",

language = "English",

volume = "27",

pages = "427--446",

journal = "International Reviews of Immunology",

issn = "0883-0185",

publisher = "Informa Healthcare",

number = "6",

}

TY - JOUR

T1 - Immunopathology of hepatitis B virus infection

AU - Tsai, Hsiu Ting

AU - Tsai, Tzu Hsin

AU - Lu, Tsong Ming

AU - Yang, Chi Chiang

PY - 2008/11

Y1 - 2008/11

N2 - The interaction between immune responses and hepatitis B virus (HBV) is coordinated between innate and adaptive immunity. Anti-HBs antibodies protect the host by blocking the binding ability of HBV. Anti-HBc antibodies are detected with persistent HBV infection. The presence of anti-HBe antibodies is often associated with recovery from active diseases and is clinically used as a benchmark to assess response to treatment. Our studies have revealed that the anti-HBV immunoglobulins secreted are different in subclass patterns in different HBV infection status populations. These revelations may help to understand HBV escape and persistent infection and to develop strategies for prevention and therapeutic management of HBV infection.

AB - The interaction between immune responses and hepatitis B virus (HBV) is coordinated between innate and adaptive immunity. Anti-HBs antibodies protect the host by blocking the binding ability of HBV. Anti-HBc antibodies are detected with persistent HBV infection. The presence of anti-HBe antibodies is often associated with recovery from active diseases and is clinically used as a benchmark to assess response to treatment. Our studies have revealed that the anti-HBV immunoglobulins secreted are different in subclass patterns in different HBV infection status populations. These revelations may help to understand HBV escape and persistent infection and to develop strategies for prevention and therapeutic management of HBV infection.

KW - Cellular immunity

KW - Hepatitis B virus

KW - Humoral immunity

KW - IgG subclass

KW - Immunopathology

KW - Regulatory T cell

UR - http://www.scopus.com/inward/record.url?scp=57449093624&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57449093624&partnerID=8YFLogxK

U2 - 10.1080/08830180802295757

DO - 10.1080/08830180802295757

M3 - Review article

C2 - 19065350

AN - SCOPUS:57449093624

SN - 0883-0185

VL - 27

SP - 427

EP - 446

JO - International Reviews of Immunology

JF - International Reviews of Immunology

IS - 6

ER -

Immunopathology of hepatitis B virus infection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this