Immunomodulatory effects of far-infrared ray irradiation via increasing calmodulin and nitric oxide production in raw 264.7 macrophages

Ting-Kai Leung; Yung Sheng Lin; Yen Chou Chen; Huey Fang Shang; Yi Hsuan Lee; Ching Hua Su; Huang Chu Liao; Tsong Min Chang

doi:10.4015/S1016237209001404

Immunomodulatory effects of far-infrared ray irradiation via increasing calmodulin and nitric oxide production in raw 264.7 macrophages

Ting-Kai Leung, Yung Sheng Lin, Yen Chou Chen, Huey Fang Shang, Yi Hsuan Lee, Ching Hua Su, Huang Chu Liao, Tsong Min Chang

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Far-infrared ray (FIR) radiation has been shown to be beneficial to human health; however, little scientific evidence of its mechanisms has been provided. In the present study, we investigated the effect of nonthermal-enhanced FIR on the expression of calmodulin (Cam) protein and nitric oxide (NO) production by RAW 264.7 macrophages. Results indicated a significant increase in Cam protein in FIR-treated RAW 264.7 macrophages with or without the addition of lipopolysaccharide (LPS). In addition, the amount of NO was slightly higher but increased significantly in FIR plus LPS-treated RAW 264.7 macrophages. Data of the present study provide the first evidence to indicate the immunomodulatory properties of FIR through increasing Cam protein and NO production in RAW 264.7 macrophages.

Original language	English
Pages (from-to)	317-323
Number of pages	7
Journal	Biomedical Engineering - Applications, Basis and Communications
Volume	21
Issue number	5
DOIs	https://doi.org/10.4015/S1016237209001404
Publication status	Published - Oct 2009

Keywords

Calmodulin
Far-infrared ray
Immunomodulation
Nitric oxide

ASJC Scopus subject areas

Bioengineering
Biophysics
Biomedical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4015/S1016237209001404

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Leung, T.-K., Lin, Y. S., Chen, Y. C., Shang, H. F., Lee, Y. H., Su, C. H., Liao, H. C., & Chang, T. M. (2009). Immunomodulatory effects of far-infrared ray irradiation via increasing calmodulin and nitric oxide production in raw 264.7 macrophages. Biomedical Engineering - Applications, Basis and Communications, 21(5), 317-323. https://doi.org/10.4015/S1016237209001404

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abstract = "Far-infrared ray (FIR) radiation has been shown to be beneficial to human health; however, little scientific evidence of its mechanisms has been provided. In the present study, we investigated the effect of nonthermal-enhanced FIR on the expression of calmodulin (Cam) protein and nitric oxide (NO) production by RAW 264.7 macrophages. Results indicated a significant increase in Cam protein in FIR-treated RAW 264.7 macrophages with or without the addition of lipopolysaccharide (LPS). In addition, the amount of NO was slightly higher but increased significantly in FIR plus LPS-treated RAW 264.7 macrophages. Data of the present study provide the first evidence to indicate the immunomodulatory properties of FIR through increasing Cam protein and NO production in RAW 264.7 macrophages.",

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author = "Ting-Kai Leung and Lin, {Yung Sheng} and Chen, {Yen Chou} and Shang, {Huey Fang} and Lee, {Yi Hsuan} and Su, {Ching Hua} and Liao, {Huang Chu} and Chang, {Tsong Min}",

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AU - Leung, Ting-Kai

AU - Lin, Yung Sheng

AU - Chen, Yen Chou

AU - Shang, Huey Fang

AU - Lee, Yi Hsuan

AU - Su, Ching Hua

AU - Liao, Huang Chu

AU - Chang, Tsong Min

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N2 - Far-infrared ray (FIR) radiation has been shown to be beneficial to human health; however, little scientific evidence of its mechanisms has been provided. In the present study, we investigated the effect of nonthermal-enhanced FIR on the expression of calmodulin (Cam) protein and nitric oxide (NO) production by RAW 264.7 macrophages. Results indicated a significant increase in Cam protein in FIR-treated RAW 264.7 macrophages with or without the addition of lipopolysaccharide (LPS). In addition, the amount of NO was slightly higher but increased significantly in FIR plus LPS-treated RAW 264.7 macrophages. Data of the present study provide the first evidence to indicate the immunomodulatory properties of FIR through increasing Cam protein and NO production in RAW 264.7 macrophages.

AB - Far-infrared ray (FIR) radiation has been shown to be beneficial to human health; however, little scientific evidence of its mechanisms has been provided. In the present study, we investigated the effect of nonthermal-enhanced FIR on the expression of calmodulin (Cam) protein and nitric oxide (NO) production by RAW 264.7 macrophages. Results indicated a significant increase in Cam protein in FIR-treated RAW 264.7 macrophages with or without the addition of lipopolysaccharide (LPS). In addition, the amount of NO was slightly higher but increased significantly in FIR plus LPS-treated RAW 264.7 macrophages. Data of the present study provide the first evidence to indicate the immunomodulatory properties of FIR through increasing Cam protein and NO production in RAW 264.7 macrophages.

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KW - Immunomodulation

KW - Nitric oxide

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Immunomodulatory effects of far-infrared ray irradiation via increasing calmodulin and nitric oxide production in raw 264.7 macrophages

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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