Immunoblot detection of antibodies to myelin basic protein in Alzheimer's disease patients

Vijendra K. Singh; Yi Yuan Yang; Edith A. Singh

doi:10.1016/0304-3940(92)90766-Z

Immunoblot detection of antibodies to myelin basic protein in Alzheimer's disease patients

Vijendra K. Singh, Yi Yuan Yang, Edith A. Singh

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Based on a suspected pathological relationship of autoimmunity in Alzheimer's disease (AD), antibodies to myelin basic protein (MBP) were investigated in the sera of AD patients, healthy controls and disease controls. As detected by the protein-immunoblotting technique at a screening serum dilution of 1:400, sera from 16 of 18 (89%) AD patients were positive for antibodies to MBP. In contrast, sera from only 7 of 90 controls (healthy adults and elderlies, Parkinson's disease patients, mentally-retarded children and Down's syndrome patients) showed a positive reaction. This approximately 11-times higher incidence of antibodies to MBP in AD patients was statistically significant (P≤0.0001) and may indicate an autoimmune process in the pathophysiology of the disease.

Original language	English
Pages (from-to)	25-28
Number of pages	4
Journal	Neuroscience Letters
Volume	147
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(92)90766-Z
Publication status	Published - Nov 23 1992
Externally published	Yes

Keywords

Alzheimer's disease
Autoantibody
Autoimmunity
Myelin basic protein

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(92)90766-Z

Cite this

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title = "Immunoblot detection of antibodies to myelin basic protein in Alzheimer's disease patients",

abstract = "Based on a suspected pathological relationship of autoimmunity in Alzheimer's disease (AD), antibodies to myelin basic protein (MBP) were investigated in the sera of AD patients, healthy controls and disease controls. As detected by the protein-immunoblotting technique at a screening serum dilution of 1:400, sera from 16 of 18 (89%) AD patients were positive for antibodies to MBP. In contrast, sera from only 7 of 90 controls (healthy adults and elderlies, Parkinson's disease patients, mentally-retarded children and Down's syndrome patients) showed a positive reaction. This approximately 11-times higher incidence of antibodies to MBP in AD patients was statistically significant (P≤0.0001) and may indicate an autoimmune process in the pathophysiology of the disease.",

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T1 - Immunoblot detection of antibodies to myelin basic protein in Alzheimer's disease patients

AU - Singh, Vijendra K.

AU - Yang, Yi Yuan

AU - Singh, Edith A.

PY - 1992/11/23

Y1 - 1992/11/23

N2 - Based on a suspected pathological relationship of autoimmunity in Alzheimer's disease (AD), antibodies to myelin basic protein (MBP) were investigated in the sera of AD patients, healthy controls and disease controls. As detected by the protein-immunoblotting technique at a screening serum dilution of 1:400, sera from 16 of 18 (89%) AD patients were positive for antibodies to MBP. In contrast, sera from only 7 of 90 controls (healthy adults and elderlies, Parkinson's disease patients, mentally-retarded children and Down's syndrome patients) showed a positive reaction. This approximately 11-times higher incidence of antibodies to MBP in AD patients was statistically significant (P≤0.0001) and may indicate an autoimmune process in the pathophysiology of the disease.

AB - Based on a suspected pathological relationship of autoimmunity in Alzheimer's disease (AD), antibodies to myelin basic protein (MBP) were investigated in the sera of AD patients, healthy controls and disease controls. As detected by the protein-immunoblotting technique at a screening serum dilution of 1:400, sera from 16 of 18 (89%) AD patients were positive for antibodies to MBP. In contrast, sera from only 7 of 90 controls (healthy adults and elderlies, Parkinson's disease patients, mentally-retarded children and Down's syndrome patients) showed a positive reaction. This approximately 11-times higher incidence of antibodies to MBP in AD patients was statistically significant (P≤0.0001) and may indicate an autoimmune process in the pathophysiology of the disease.

KW - Alzheimer's disease

KW - Autoantibody

KW - Autoimmunity

KW - Myelin basic protein

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Immunoblot detection of antibodies to myelin basic protein in Alzheimer's disease patients

Abstract

Keywords

ASJC Scopus subject areas

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