TY - JOUR
T1 - Immune modulation properties of herbal plant leaves
T2 - Phyllanthus niruri aqueous extract on immune cells of tuberculosis patient - in vitro study
AU - Putri, Denise Utami
AU - Rintiswati, Ning
AU - Soesatyo, Marsetyawan H.N.E.
AU - Haryana, Sofia Mubarika
N1 - Publisher Copyright:
© 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2018/2/16
Y1 - 2018/2/16
N2 - Disease progression in Tuberculosis (TB) is dependent on host’s immune system. Phyllanthus niruri, a traditional herb, has long been used to boost immune system in Indonesian society. This study aimed to observe the potential role of P. niruri in inducing immune cells activity in TB patients by in vitro approach. Peripheral blood mononuclear cells (PBMCs) and macrophages were collected from active pulmonary TB patients. After stimulation with graded doses of P. niruri aqueous extract, cell proliferation, phagocytic activity and nitric oxide (NO) release were analysed. P. niruri aqueous extract induced proliferation of PBMCs, increased NO release, and improved macrophages phagocytic activity. These effects were observed in a dose-dependent manner. This may lead to further research for the potential role of P. niruri as immunomodulatory adjuvant therapy for TB patients.
AB - Disease progression in Tuberculosis (TB) is dependent on host’s immune system. Phyllanthus niruri, a traditional herb, has long been used to boost immune system in Indonesian society. This study aimed to observe the potential role of P. niruri in inducing immune cells activity in TB patients by in vitro approach. Peripheral blood mononuclear cells (PBMCs) and macrophages were collected from active pulmonary TB patients. After stimulation with graded doses of P. niruri aqueous extract, cell proliferation, phagocytic activity and nitric oxide (NO) release were analysed. P. niruri aqueous extract induced proliferation of PBMCs, increased NO release, and improved macrophages phagocytic activity. These effects were observed in a dose-dependent manner. This may lead to further research for the potential role of P. niruri as immunomodulatory adjuvant therapy for TB patients.
KW - herbal plant
KW - immune modulation
KW - phagocytic activity
KW - Phyllanthus niruri
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=85017232192&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017232192&partnerID=8YFLogxK
U2 - 10.1080/14786419.2017.1311888
DO - 10.1080/14786419.2017.1311888
M3 - Article
C2 - 28391709
AN - SCOPUS:85017232192
SN - 1478-6419
VL - 32
SP - 463
EP - 467
JO - Natural Product Research
JF - Natural Product Research
IS - 4
ER -
