Imaging of regional metabolic activity by 18F-FDG/PET in rats with transient cerebral ischemia

Ying Kai Fu; Chia Jung Chang; Kuan Yin Chen; Li Chung Hwang; Kuo Hung Wu; Kang Wei Chang; Meei Ling Jan; Chia Chieh Chen; Chih Hsien Chang

doi:10.1016/j.apradiso.2009.03.002

Imaging of regional metabolic activity by ¹⁸F-FDG/PET in rats with transient cerebral ischemia

Ying Kai Fu, Chia Jung Chang, Kuan Yin Chen, Li Chung Hwang, Kuo Hung Wu, Kang Wei Chang, Meei Ling Jan, Chia Chieh Chen, Chih Hsien Chang

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that ¹⁸F-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-acute metabolic variations in infarct regions. We found that imaging with ¹⁸F-FDG/PET enabled detection and quantification of ischemia-induced metabolic deficits and provided a sensitive and reliable means of assessing cerebral ischemic lesions compared with conventional neurological scoring systems in rodents.

Original language	English
Pages (from-to)	1743-1747
Number of pages	5
Journal	Applied Radiation and Isotopes
Volume	67
Issue number	10
DOIs	https://doi.org/10.1016/j.apradiso.2009.03.002
Publication status	Published - Oct 1 2009
Externally published	Yes

Keywords

F-FDG
MicroPET
Rat ischemia model

ASJC Scopus subject areas

Radiation

Access to Document

10.1016/j.apradiso.2009.03.002

Cite this

@article{904b0b6bdcff427ca7c275cda34c3b29,

title = "Imaging of regional metabolic activity by 18F-FDG/PET in rats with transient cerebral ischemia",

abstract = "Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that 18F-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-acute metabolic variations in infarct regions. We found that imaging with 18F-FDG/PET enabled detection and quantification of ischemia-induced metabolic deficits and provided a sensitive and reliable means of assessing cerebral ischemic lesions compared with conventional neurological scoring systems in rodents.",

keywords = "F-FDG, MicroPET, Rat ischemia model",

author = "Fu, {Ying Kai} and Chang, {Chia Jung} and Chen, {Kuan Yin} and Hwang, {Li Chung} and Wu, {Kuo Hung} and Chang, {Kang Wei} and Jan, {Meei Ling} and Chen, {Chia Chieh} and Chang, {Chih Hsien}",

note = "Funding Information: This research was supported by the National Science Council and the Institute of Nuclear Energy Research, Taiwan, ROC. The authors are grateful to Dr. Wuu-Jyh Lin for providing 18 F-FDG, to Mr. Kuo-Wei Chen for his help with image data reconstruction to Professor Yui-whei Chen-Yang, Chung Yuan Christian University, for her knowledgeable discussion on the manuscript, and to Ms. Hsueh-Hsuan Liu for her supervision on animal experiments.",

year = "2009",

month = oct,

day = "1",

doi = "10.1016/j.apradiso.2009.03.002",

language = "English",

volume = "67",

pages = "1743--1747",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Limited",

number = "10",

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TY - JOUR

T1 - Imaging of regional metabolic activity by 18F-FDG/PET in rats with transient cerebral ischemia

AU - Fu, Ying Kai

AU - Chang, Chia Jung

AU - Chen, Kuan Yin

AU - Hwang, Li Chung

AU - Wu, Kuo Hung

AU - Chang, Kang Wei

AU - Jan, Meei Ling

AU - Chen, Chia Chieh

AU - Chang, Chih Hsien

N1 - Funding Information: This research was supported by the National Science Council and the Institute of Nuclear Energy Research, Taiwan, ROC. The authors are grateful to Dr. Wuu-Jyh Lin for providing 18 F-FDG, to Mr. Kuo-Wei Chen for his help with image data reconstruction to Professor Yui-whei Chen-Yang, Chung Yuan Christian University, for her knowledgeable discussion on the manuscript, and to Ms. Hsueh-Hsuan Liu for her supervision on animal experiments.

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that 18F-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-acute metabolic variations in infarct regions. We found that imaging with 18F-FDG/PET enabled detection and quantification of ischemia-induced metabolic deficits and provided a sensitive and reliable means of assessing cerebral ischemic lesions compared with conventional neurological scoring systems in rodents.

AB - Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that 18F-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-acute metabolic variations in infarct regions. We found that imaging with 18F-FDG/PET enabled detection and quantification of ischemia-induced metabolic deficits and provided a sensitive and reliable means of assessing cerebral ischemic lesions compared with conventional neurological scoring systems in rodents.

KW - F-FDG

KW - MicroPET

KW - Rat ischemia model

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