IL-20: Biological functions and clinical implications

Chi Chen Wei, Yu Hsiang Hsu, Hsing Hui Li, Yo Ching Wang, Mei Yi Hsieh, Wei Yu Chen, Chung-Hsi Hsing, Ming Shi Chang

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)


IL-20 belongs to the IL-10 family and plays a role in skin inflammation and the development of hematopoietic cells. Little is known about its other biological functions and clinical implications, however. Updated information about IL-20, such as its identification, expression, receptors, signaling, biological activities, and potential clinical implications, is illustrated in this review based on our research and on data available in the literature. Our studies of IL-20 show that it is a pleiotropic cytokine with potent inflammatory, angiogenic, and chemoattractive characteristics. Inflammation and angiogenesis are essential for the pathogenesis of rheumatoid arthritis and atherosclerosis. Based on in vitro data and clinical samples, we demonstrated that IL-20 is involved in the diseases of rheumatoid arthritis and atherosclerosis. In addition, we found in our studies that IL-20 signaled through different molecules in several cells. The present review presents the clinical implications of IL-20 in rheumatoid arthritis and atherosclerosis. It may provide new therapeutic options in the future.

Original languageEnglish
Pages (from-to)601-612
Number of pages12
JournalJournal of Biomedical Science
Issue number5
Publication statusPublished - Sept 2006
Externally publishedYes


  • Angiogenesis
  • Atherosclerosis
  • IL-20
  • Inflammation
  • Psoriasis
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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