TY - JOUR
T1 - IFN-γ auto-antibody
T2 - An overview as one of the autoimmunity effect
AU - Krisnawati, Dyah Ika
AU - Rahayu, Dwi
AU - Rinawati, Fajar
AU - Susilowati, Erna
AU - Santoso, Puguh
AU - Darmayanti, Rofik
AU - Puspitasari, Betristasia
AU - Yunarsih,
AU - Sucipto,
AU - Kuo, Tsung Rong
N1 - Publisher Copyright:
© 2024 by author(s).
PY - 2024
Y1 - 2024
N2 - Interferon Gamma (IFN-γ) plays a vital role in normal immune surveillance and possesses immunomodulatory, antimicrobial, and anticancer properties. It stands as the exclusive type II IFN, and its production is regulated by cytokines released by Antigen-Presenting Cells (APCs), particularly interleukin (IL)-12 and IL-18. These cytokines act as a connecting link between infection and IFN-γ production in the innate immune response. The functional IFN-γ receptor (IFNGR) consists of two ligand-binding IFNGR1 chains and two signal-transducing IFNGR2 chains, along with associated signaling machinery. Both IFNGR1 and IFNGR2 chains belong to the class II cytokine receptor family, characterized by ligand binding in the small angle of a V formed by the two Ig-like folds in the extracellular domain. Autoantibodies targeting interferon-gamma (IFN-γ) can lead to immunodeficiency and are linked to various opportunistic infections. The immunopathogenesis is associated with the neutralizing activity of these autoantibodies on the IFN-γ signaling pathway, resulting in the blocking of certain immune responses activated by IFN-γ. This review provides a concise overview of IFN-γ Autoantibody detection, the immunopathogenesis of related diseases, and potential treatment options.
AB - Interferon Gamma (IFN-γ) plays a vital role in normal immune surveillance and possesses immunomodulatory, antimicrobial, and anticancer properties. It stands as the exclusive type II IFN, and its production is regulated by cytokines released by Antigen-Presenting Cells (APCs), particularly interleukin (IL)-12 and IL-18. These cytokines act as a connecting link between infection and IFN-γ production in the innate immune response. The functional IFN-γ receptor (IFNGR) consists of two ligand-binding IFNGR1 chains and two signal-transducing IFNGR2 chains, along with associated signaling machinery. Both IFNGR1 and IFNGR2 chains belong to the class II cytokine receptor family, characterized by ligand binding in the small angle of a V formed by the two Ig-like folds in the extracellular domain. Autoantibodies targeting interferon-gamma (IFN-γ) can lead to immunodeficiency and are linked to various opportunistic infections. The immunopathogenesis is associated with the neutralizing activity of these autoantibodies on the IFN-γ signaling pathway, resulting in the blocking of certain immune responses activated by IFN-γ. This review provides a concise overview of IFN-γ Autoantibody detection, the immunopathogenesis of related diseases, and potential treatment options.
KW - autoantibody
KW - detection
KW - immunopathogenesis
KW - interferon gamma
KW - treatment
UR - http://www.scopus.com/inward/record.url?scp=85195491096&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85195491096&partnerID=8YFLogxK
U2 - 10.24294/ti.v8.i1.4562
DO - 10.24294/ti.v8.i1.4562
M3 - Review article
AN - SCOPUS:85195491096
SN - 2573-5985
VL - 8
JO - Trends in Immunotherapy
JF - Trends in Immunotherapy
IS - 1
M1 - 4562
ER -