Idiopathic growth hormone deficiency in the morphologically normal pituitary gland is associated with perfusion delay

Chao Ying Wang, Hsiao Wen Chung, Nai Yu Cho, Hua Shan Liu, Ming Chung Chou, Hung Wen Kao, Chun Jung Juan, Meei Shyuan Lee, Guo Shu Huang, Cheng Yu Chen

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Purpose: To investigate quantitatively the topographic perfusion characteristics of the adenohypophysis by using dynamic contrast material-enhanced magnetic resonance (MR) imaging in a subgroup of patients with idiopathic growth hormone deficiency (IGHD) and with normal-appearing pituitary morphology on MR images. Materials and Methods: This HIPAA-compliant, prospective study was approved by an institutional review board, and informed consent was obtained for all patients. Twenty-five patients (mean age, 10.6 years ±3.3 [standard deviation]) with clinical growth retardation, proved IGHD, and normal pituitary morphology on MR images were included for analysis. Sixteen children (mean age, 10.8 years ± 5.5) were included as control subjects. Time to peak (TTP) perfusion properties of the adenohypophysis in 10 regions of interest from multisection coronal dynamic contrast-enhanced T1-weighted MR images were quantitatively derived by using the Brix pharmacokinetic model. Significant difference was determined with a two-tailed Student t test. The Pearson correlation coefficient was used to correlate the perfusion parameters, including maximal enhancement peak and slope, with serum growth hormone levels in the IGHD group. Results: TTP for the IGHD group was significantly prolonged compared with that for the control group (P

Original languageEnglish
Pages (from-to)213-221
Number of pages9
Issue number1
Publication statusPublished - Jan 2011
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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