TY - JOUR
T1 - Identification of two novel HLA-A*02 variants, A*02
T2 - 319 and A*02:01:64, in two Taiwanese marrow stem cell donors by sequence-based typing
AU - Yang, K. L.
AU - Lee, S. K.
AU - Yang, S. Y.
AU - Kao, R. H.
AU - Lin, C. L.
AU - Lin, P. Y.
PY - 2012/6/1
Y1 - 2012/6/1
N2 - We report here two novel variants of HLA-A*02 allele, A*02:319 and A*02:01:64, discovered in two Taiwanese unrelated volunteer bone marrow donors by sequence-based typing (SBT) method. The DNA sequence of A*02:319 is identical to A*02:07 in exons 2 and 3 but varies with one nucleotide at codon 9 (TTC->TCC). The variation caused one amino acid substitution at residue 9 (F->S). On the other hand, the DNA sequence of A*02:01:64 is identical to the sequence of A*02:01:01:01 in exons 2 and 3 except a silent mutation at codon 114 (CAC->CAT). The probable HLA-A, HLA-B and HLA-DRB1 haplotypes in association with A*02:319 and A*02:01:64 were deduced as A*02:319-B*46:01-DRB1*04 and A*02:01:64-B*38:02-DRB1*16:02, respectively.
AB - We report here two novel variants of HLA-A*02 allele, A*02:319 and A*02:01:64, discovered in two Taiwanese unrelated volunteer bone marrow donors by sequence-based typing (SBT) method. The DNA sequence of A*02:319 is identical to A*02:07 in exons 2 and 3 but varies with one nucleotide at codon 9 (TTC->TCC). The variation caused one amino acid substitution at residue 9 (F->S). On the other hand, the DNA sequence of A*02:01:64 is identical to the sequence of A*02:01:01:01 in exons 2 and 3 except a silent mutation at codon 114 (CAC->CAT). The probable HLA-A, HLA-B and HLA-DRB1 haplotypes in association with A*02:319 and A*02:01:64 were deduced as A*02:319-B*46:01-DRB1*04 and A*02:01:64-B*38:02-DRB1*16:02, respectively.
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U2 - 10.1111/j.1744-313X.2011.01080.x
DO - 10.1111/j.1744-313X.2011.01080.x
M3 - Article
C2 - 22221707
AN - SCOPUS:84860916036
SN - 1744-3121
VL - 39
SP - 261
EP - 263
JO - International Journal of Immunogenetics
JF - International Journal of Immunogenetics
IS - 3
ER -