Identification of subgroup patients with stage IIIB/IV non-small cell lung cancer at higher risk for brain metastases

Shih Hsin Hsiao; Chi Li Chung; Yu Ting Chou; Hsin Lun Lee; Sey En Lin; H. Eugene Liu

doi:10.1016/j.lungcan.2013.08.004

Identification of subgroup patients with stage IIIB/IV non-small cell lung cancer at higher risk for brain metastases

Shih Hsin Hsiao, Chi Li Chung, Yu Ting Chou, Hsin Lun Lee, Sey En Lin, H. Eugene Liu

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Purpose: Brain metastases (BM), a common occurrence in non-small cell lung cancer (NSCLC), usually lead to a poor prognosis. Recently, the selection of treatment modalities for BM has modestly improved patient survival and quality of life. Treatment choice is largely based on the number of BM, the presence of BM-related symptoms, and performance status. Therefore, early BM detection is crucial. In this study, we aimed to elucidate the factors associated with BM and identify subgroups of patients at higher risk for BM. Methods and patients: The medical records of 596 consecutive patients with stage I-IV NSCLC were reviewed between January 2006 and November 2011. A multivariate logistic regression (MLR) model was used to identify factors associated with BM. Results: Among 482 eligible stage IIIB/IV NSCLC patients, 173 (36%) experienced BM during their disease course. On MLR analysis, female gender, age

Original language	English
Pages (from-to)	319-323
Number of pages	5
Journal	Lung Cancer
Volume	82
Issue number	2
DOIs	https://doi.org/10.1016/j.lungcan.2013.08.004
Publication status	Published - Nov 2013

Keywords

Actuarial incidence of brain metastases
Adenocarcinoma
Early detection
Identification of subgroup patients at higher risk
Non-small cell lung cancer
Young age

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.lungcan.2013.08.004

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@article{38e806a4880e4b7cadfb1e09e7fcf02a,

title = "Identification of subgroup patients with stage IIIB/IV non-small cell lung cancer at higher risk for brain metastases",

abstract = "Purpose: Brain metastases (BM), a common occurrence in non-small cell lung cancer (NSCLC), usually lead to a poor prognosis. Recently, the selection of treatment modalities for BM has modestly improved patient survival and quality of life. Treatment choice is largely based on the number of BM, the presence of BM-related symptoms, and performance status. Therefore, early BM detection is crucial. In this study, we aimed to elucidate the factors associated with BM and identify subgroups of patients at higher risk for BM. Methods and patients: The medical records of 596 consecutive patients with stage I-IV NSCLC were reviewed between January 2006 and November 2011. A multivariate logistic regression (MLR) model was used to identify factors associated with BM. Results: Among 482 eligible stage IIIB/IV NSCLC patients, 173 (36%) experienced BM during their disease course. On MLR analysis, female gender, age ",

keywords = "Actuarial incidence of brain metastases, Adenocarcinoma, Early detection, Identification of subgroup patients at higher risk, Non-small cell lung cancer, Young age",

author = "Hsiao, {Shih Hsin} and Chung, {Chi Li} and Chou, {Yu Ting} and Lee, {Hsin Lun} and Lin, {Sey En} and Liu, {H. Eugene}",

note = "Funding Information: This study was supported in part by the Grant from the Taipei Medical University and Hospital ( TMU100-AE3-Y16 ).",

year = "2013",

month = nov,

doi = "10.1016/j.lungcan.2013.08.004",

language = "English",

volume = "82",

pages = "319--323",

journal = "Lung Cancer",

issn = "0169-5002",

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TY - JOUR

T1 - Identification of subgroup patients with stage IIIB/IV non-small cell lung cancer at higher risk for brain metastases

AU - Hsiao, Shih Hsin

AU - Chung, Chi Li

AU - Chou, Yu Ting

AU - Lee, Hsin Lun

AU - Lin, Sey En

AU - Liu, H. Eugene

N1 - Funding Information: This study was supported in part by the Grant from the Taipei Medical University and Hospital ( TMU100-AE3-Y16 ).

PY - 2013/11

Y1 - 2013/11

N2 - Purpose: Brain metastases (BM), a common occurrence in non-small cell lung cancer (NSCLC), usually lead to a poor prognosis. Recently, the selection of treatment modalities for BM has modestly improved patient survival and quality of life. Treatment choice is largely based on the number of BM, the presence of BM-related symptoms, and performance status. Therefore, early BM detection is crucial. In this study, we aimed to elucidate the factors associated with BM and identify subgroups of patients at higher risk for BM. Methods and patients: The medical records of 596 consecutive patients with stage I-IV NSCLC were reviewed between January 2006 and November 2011. A multivariate logistic regression (MLR) model was used to identify factors associated with BM. Results: Among 482 eligible stage IIIB/IV NSCLC patients, 173 (36%) experienced BM during their disease course. On MLR analysis, female gender, age

AB - Purpose: Brain metastases (BM), a common occurrence in non-small cell lung cancer (NSCLC), usually lead to a poor prognosis. Recently, the selection of treatment modalities for BM has modestly improved patient survival and quality of life. Treatment choice is largely based on the number of BM, the presence of BM-related symptoms, and performance status. Therefore, early BM detection is crucial. In this study, we aimed to elucidate the factors associated with BM and identify subgroups of patients at higher risk for BM. Methods and patients: The medical records of 596 consecutive patients with stage I-IV NSCLC were reviewed between January 2006 and November 2011. A multivariate logistic regression (MLR) model was used to identify factors associated with BM. Results: Among 482 eligible stage IIIB/IV NSCLC patients, 173 (36%) experienced BM during their disease course. On MLR analysis, female gender, age

KW - Actuarial incidence of brain metastases

KW - Adenocarcinoma

KW - Early detection

KW - Identification of subgroup patients at higher risk

KW - Non-small cell lung cancer

KW - Young age

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JF - Lung Cancer

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Identification of subgroup patients with stage IIIB/IV non-small cell lung cancer at higher risk for brain metastases

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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