Identification of flurbiprofen and its photoproducts in methanol by gas chromatography-mass spectrometry

Su Hui Chao; Hsin Tsung Ho; Fu An Chen; Pen Yuan Lin; Yi Chun Yu; An-Bang Wu

doi:10.1002/bmc.789

Identification of flurbiprofen and its photoproducts in methanol by gas chromatography-mass spectrometry

Su Hui Chao, Hsin Tsung Ho, Fu An Chen, Pen Yuan Lin, Yi Chun Yu, An-Bang Wu

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A sample of 10 mM flurbiprofen in methanol (or ethanol) was photoirradiated with sixteen 8 W low-pressure quartz mercury lamps irradiated at 306 nm in a Panchum PR-2000 photochemical reactor. In total, four major photoproducts derived from each sample were observed from the HPLC chromatogram. The photoproducts were separated and their structures elucidated by various spectroscopic methods. Alternatively, using GC-MS, 11 major photoproducts were observed. A reaction scheme of flurbiprofen in methanol is proposed: the photochemical reaction routes occur mainly via esterification and decarboxylation, followed by oxidation with singlet oxygen to produce a ketone, alcohols and other derivatives.

Original language	English
Pages (from-to)	527-533
Number of pages	7
Journal	Biomedical Chromatography
Volume	21
Issue number	5
DOIs	https://doi.org/10.1002/bmc.789
Publication status	Published - May 2007

Keywords

Flurbiprofen
GC-MS
HPLC
Photoproducts

ASJC Scopus subject areas

Drug Discovery
Analytical Chemistry
Molecular Biology
Biochemistry
Clinical Biochemistry
Pharmacology

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10.1002/bmc.789

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title = "Identification of flurbiprofen and its photoproducts in methanol by gas chromatography-mass spectrometry",

abstract = "A sample of 10 mM flurbiprofen in methanol (or ethanol) was photoirradiated with sixteen 8 W low-pressure quartz mercury lamps irradiated at 306 nm in a Panchum PR-2000 photochemical reactor. In total, four major photoproducts derived from each sample were observed from the HPLC chromatogram. The photoproducts were separated and their structures elucidated by various spectroscopic methods. Alternatively, using GC-MS, 11 major photoproducts were observed. A reaction scheme of flurbiprofen in methanol is proposed: the photochemical reaction routes occur mainly via esterification and decarboxylation, followed by oxidation with singlet oxygen to produce a ketone, alcohols and other derivatives.",

keywords = "Flurbiprofen, GC-MS, HPLC, Photoproducts",

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T1 - Identification of flurbiprofen and its photoproducts in methanol by gas chromatography-mass spectrometry

AU - Chao, Su Hui

AU - Ho, Hsin Tsung

AU - Chen, Fu An

AU - Lin, Pen Yuan

AU - Yu, Yi Chun

AU - Wu, An-Bang

PY - 2007/5

Y1 - 2007/5

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AB - A sample of 10 mM flurbiprofen in methanol (or ethanol) was photoirradiated with sixteen 8 W low-pressure quartz mercury lamps irradiated at 306 nm in a Panchum PR-2000 photochemical reactor. In total, four major photoproducts derived from each sample were observed from the HPLC chromatogram. The photoproducts were separated and their structures elucidated by various spectroscopic methods. Alternatively, using GC-MS, 11 major photoproducts were observed. A reaction scheme of flurbiprofen in methanol is proposed: the photochemical reaction routes occur mainly via esterification and decarboxylation, followed by oxidation with singlet oxygen to produce a ketone, alcohols and other derivatives.

KW - Flurbiprofen

KW - GC-MS

KW - HPLC

KW - Photoproducts

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Identification of flurbiprofen and its photoproducts in methanol by gas chromatography-mass spectrometry

Abstract

Keywords

ASJC Scopus subject areas

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