Identification of FKBP11 as a biomarker for hepatocellular carcinoma

I. Yin Lin; Chia Hung Yen; Yi Jen Liao; Sey-En Lin; Hon Ping Ma; Yu Jiun Chan; Yi Ming A Chen

Identification of FKBP11 as a biomarker for hepatocellular carcinoma

I. Yin Lin
, Chia Hung Yen
, Yi Jen Liao
, Sey-En Lin
, Hon Ping Ma
, Yu Jiun Chan
, Yi Ming A Chen

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11. Patients and Methods: FKBP11 expression levels were analyzed in 123 paired tumor and tumor-Adjacent non-tumorous (TA) tissue samples from patients with HCC and in 29 benign liver samples from patients with hemangioma using quantitative real-time polymerase-chain-reaction. Results: FKBP11 was expressed at a higher level in tumor tissues compared to TA tissues (p

Original language	English
Pages (from-to)	2763-2770
Number of pages	8
Journal	Anticancer Research
Volume	33
Issue number	6
Publication status	Published - Jun 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

FK506 binding protein
FKBP11
FKBP19
GNMT
HCC

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Identification of FKBP11 as a biomarker for hepatocellular carcinoma",

abstract = "Background: Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11. Patients and Methods: FKBP11 expression levels were analyzed in 123 paired tumor and tumor-Adjacent non-tumorous (TA) tissue samples from patients with HCC and in 29 benign liver samples from patients with hemangioma using quantitative real-time polymerase-chain-reaction. Results: FKBP11 was expressed at a higher level in tumor tissues compared to TA tissues (p",

keywords = "FK506 binding protein, FKBP11, FKBP19, GNMT, HCC",

author = "Lin, \{I. Yin\} and Yen, \{Chia Hung\} and Liao, \{Yi Jen\} and Sey-En Lin and Ma, \{Hon Ping\} and Chan, \{Yu Jiun\} and Chen, \{Yi Ming A\}",

year = "2013",

month = jun,

language = "English",

volume = "33",

pages = "2763--2770",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "6",

}

TY - JOUR

T1 - Identification of FKBP11 as a biomarker for hepatocellular carcinoma

AU - Lin, I. Yin

AU - Yen, Chia Hung

AU - Liao, Yi Jen

AU - Lin, Sey-En

AU - Ma, Hon Ping

AU - Chan, Yu Jiun

AU - Chen, Yi Ming A

PY - 2013/6

Y1 - 2013/6

N2 - Background: Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11. Patients and Methods: FKBP11 expression levels were analyzed in 123 paired tumor and tumor-Adjacent non-tumorous (TA) tissue samples from patients with HCC and in 29 benign liver samples from patients with hemangioma using quantitative real-time polymerase-chain-reaction. Results: FKBP11 was expressed at a higher level in tumor tissues compared to TA tissues (p

AB - Background: Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11. Patients and Methods: FKBP11 expression levels were analyzed in 123 paired tumor and tumor-Adjacent non-tumorous (TA) tissue samples from patients with HCC and in 29 benign liver samples from patients with hemangioma using quantitative real-time polymerase-chain-reaction. Results: FKBP11 was expressed at a higher level in tumor tissues compared to TA tissues (p

KW - FK506 binding protein

KW - FKBP11

KW - FKBP19

KW - GNMT

KW - HCC

UR - https://www.scopus.com/pages/publications/84881331173

UR - https://www.scopus.com/pages/publications/84881331173#tab=citedBy

M3 - Article

C2 - 23749938

AN - SCOPUS:84881331173

SN - 0250-7005

VL - 33

SP - 2763

EP - 2770

JO - Anticancer Research

JF - Anticancer Research

IS - 6

ER -

Identification of FKBP11 as a biomarker for hepatocellular carcinoma

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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