Identification of FKBP11 as a biomarker for hepatocellular carcinoma

I. Yin Lin; Chia Hung Yen; Yi Jen Liao; Sey-En Lin; Hon Ping Ma; Yu Jiun Chan; Yi Ming A Chen

Identification of FKBP11 as a biomarker for hepatocellular carcinoma

I. Yin Lin, Chia Hung Yen, Yi Jen Liao, Sey-En Lin, Hon Ping Ma, Yu Jiun Chan, Yi Ming A Chen

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11. Patients and Methods: FKBP11 expression levels were analyzed in 123 paired tumor and tumor-Adjacent non-tumorous (TA) tissue samples from patients with HCC and in 29 benign liver samples from patients with hemangioma using quantitative real-time polymerase-chain-reaction. Results: FKBP11 was expressed at a higher level in tumor tissues compared to TA tissues (p

Original language	English
Pages (from-to)	2763-2770
Number of pages	8
Journal	Anticancer Research
Volume	33
Issue number	6
Publication status	Published - Jun 2013

Keywords

FK506 binding protein
FKBP11
FKBP19
GNMT
HCC

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Identification of FKBP11 as a biomarker for hepatocellular carcinoma",

abstract = "Background: Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11. Patients and Methods: FKBP11 expression levels were analyzed in 123 paired tumor and tumor-Adjacent non-tumorous (TA) tissue samples from patients with HCC and in 29 benign liver samples from patients with hemangioma using quantitative real-time polymerase-chain-reaction. Results: FKBP11 was expressed at a higher level in tumor tissues compared to TA tissues (p",

keywords = "FK506 binding protein, FKBP11, FKBP19, GNMT, HCC",

author = "Lin, {I. Yin} and Yen, {Chia Hung} and Liao, {Yi Jen} and Sey-En Lin and Ma, {Hon Ping} and Chan, {Yu Jiun} and Chen, {Yi Ming A}",

year = "2013",

month = jun,

language = "English",

volume = "33",

pages = "2763--2770",

journal = "Anticancer Research",

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}

TY - JOUR

T1 - Identification of FKBP11 as a biomarker for hepatocellular carcinoma

AU - Lin, I. Yin

AU - Yen, Chia Hung

AU - Liao, Yi Jen

AU - Lin, Sey-En

AU - Ma, Hon Ping

AU - Chan, Yu Jiun

AU - Chen, Yi Ming A

PY - 2013/6

Y1 - 2013/6

N2 - Background: Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11. Patients and Methods: FKBP11 expression levels were analyzed in 123 paired tumor and tumor-Adjacent non-tumorous (TA) tissue samples from patients with HCC and in 29 benign liver samples from patients with hemangioma using quantitative real-time polymerase-chain-reaction. Results: FKBP11 was expressed at a higher level in tumor tissues compared to TA tissues (p

AB - Background: Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11. Patients and Methods: FKBP11 expression levels were analyzed in 123 paired tumor and tumor-Adjacent non-tumorous (TA) tissue samples from patients with HCC and in 29 benign liver samples from patients with hemangioma using quantitative real-time polymerase-chain-reaction. Results: FKBP11 was expressed at a higher level in tumor tissues compared to TA tissues (p

KW - FK506 binding protein

KW - FKBP11

KW - FKBP19

KW - GNMT

KW - HCC

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M3 - Article

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AN - SCOPUS:84881331173

SN - 0250-7005

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JO - Anticancer Research

JF - Anticancer Research

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ER -

Identification of FKBP11 as a biomarker for hepatocellular carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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