TY - JOUR
T1 - Hyperthermia Potentiates Doxorubicin-Related Cardiotoxic Effects
AU - Kim, Young Duk
AU - Lees, David Eric
AU - Lake, Charles R.
AU - Whang-Peng, Jacqueline
AU - Bull, Joan
AU - Schuette, William
AU - Smith, Rosalie
PY - 1979/4/27
Y1 - 1979/4/27
N2 - The intercurrent administration of doxorubicin hydrochloride to a patient undergoing whole-body hyperthermia for the treatment of metastatic cancer repeatedly produced ventricular irritability and cardiac dysfunction. Individually, doxorubicin and hyperthermia were tolerated by the patient without incident. Catecholamine determinations showed that the administration of doxorubicin under hyperthermic conditions increased the liberation of both epinephrine and norepinephrine. The acute synergistic cardiotoxic effects occurred with doxorubicin dosages that were severalfold less than those associated with only mild and transient ECG disturbances under normothermic conditions.
AB - The intercurrent administration of doxorubicin hydrochloride to a patient undergoing whole-body hyperthermia for the treatment of metastatic cancer repeatedly produced ventricular irritability and cardiac dysfunction. Individually, doxorubicin and hyperthermia were tolerated by the patient without incident. Catecholamine determinations showed that the administration of doxorubicin under hyperthermic conditions increased the liberation of both epinephrine and norepinephrine. The acute synergistic cardiotoxic effects occurred with doxorubicin dosages that were severalfold less than those associated with only mild and transient ECG disturbances under normothermic conditions.
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U2 - 10.1001/jama.1979.03290430034020
DO - 10.1001/jama.1979.03290430034020
M3 - Article
C2 - 430749
AN - SCOPUS:84945703491
SN - 0002-9955
VL - 241
SP - 1816
EP - 1817
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
IS - 17
ER -
