Abstract
A modified Windkessel model was used to investigate interactions between peripheral resistance and ejection fraction in determining hypertension. Experimental aortic pressure, Pa(t), and aortic flow, Qa(t), data from mongrel dogs with an average of 23 kg were digitized and then incorporated into a three-element lumped arterial system model. By manipulating peripheral resistance (Rs), systemic capacitance (Cs), and Qa(t), the Pa(t) was studied. Results indicated that elevated Pa(t) caused by increased ejection fraction (EF) can be observed within normal or reduced peripheral impedance. Thus anti-hypertensive drugs using vasodilator could not be effective if cardiac origin of hypertension is involved.
| Original language | English |
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| Title of host publication | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Publisher | IEEE |
| Pages | 247 |
| Number of pages | 1 |
| Volume | 1 |
| ISBN (Print) | 0780356756 |
| Publication status | Published - 1999 |
| Externally published | Yes |
| Event | Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA Duration: Oct 13 1999 → Oct 16 1999 |
Other
| Other | Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) |
|---|---|
| City | Atlanta, GA, USA |
| Period | 10/13/99 → 10/16/99 |
ASJC Scopus subject areas
- Bioengineering