Hypersensitivity of bronchopulmonary C-fibers induced by airway mucosal inflammation: Cellular mechanisms

Lu Yuan Lee, Kevin Kwong, You Shuei Lin, Qihai Gu

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)


Stimulation of vagal bronchopulmonary C-fibers induces bronchoconstriction and hypersecretion of mucus, and is either directly or indirectly involved in eliciting cough reflex. Our recent studies have shown that the excitability of these afferents is markedly elevated in experimental conditions involving acute injury or inflammation of airway mucosa (e.g. after exposure to ozone), and cyclo-oxygenase metabolites of arachidonic acid locally released in the airways may contribute partially to the C-fiber hypersensitivity. Among the various prostanoids, prostaglandin E2 administered by slow infusion augmented the responses of pulmonary C-fibers to both lung inflation and various chemical stimulants in anesthetized rats. The PGE2-induced hypersensitivity of these sensory nerves could also be demonstrated in cultured neurons using the whole-cell perforated patch-clamp recording technique; PGE2 perfusion markedly and reversibly increased both the magnitude of inward current (in voltage-clamp mode) and the number of action potentials (in current-clamp mode) evoked by capsaicin in the small-diameter nodose and jugular ganglion neurons isolated from adult rats. Moreover, PGE2 enhanced the membrane excitability of these neurons in their response to injected current pulses and voltage steps. In conclusion, the sensitizing effect is caused by a direct action of PGE2 on pulmonary C-fibers, and the cAMP/protein kinase A transduction cascade is probably involved.

Original languageEnglish
Pages (from-to)199-204
Number of pages6
JournalPulmonary Pharmacology and Therapeutics
Issue number3
Publication statusPublished - 2002


  • Airway irritation
  • Bronchial hyperreactivity
  • C-fibers
  • Prostaglandin E
  • Vagus nerve

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Biochemistry, medical
  • Pharmacology (medical)


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