Hyperparathyroidism, glucose tolerance and platelet intracellular free calcium in chronic renal failure

Kuo Cheng Lu, S. D. Shieh, S. H. Lin, S. H. Chyr, Y. F. Lin, L. K. Diang, B. L. Li, W. H.H. Sheu, Y. A. Ding

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Disturbance in the vitamin D/parathyroid hormone (PTH) axis may be important in the pathogenesis of glucose intolerance and insulin resistance in uraemia. To investigate possible relationships between hyperparathyroidism, intracellular free calcium ([Ca2+]1), and glucose tolerance in chronic renal failure, we measured serum intact PTH (l-PTH) by two-site immunometric assay, platelet [Ca2+]1 using the fluorescent indicator fura-2, and plasma glucose and insulin after 14 h overnight fast and at 30, 60 and 120 min following a 75 g oral glucose load, in 18 chronic haemodialysis patients with elevated serum l-PTH. Calcitriol (1 μg) was administered parenterally at the end of each dialysis session for four weeks. This significantly decreased serum l-PTH (p<0.001) and platelet [Ca2+], (p<0.01). Uraemic patients initially showed marked glucose intolerance, with increased area below the glucose curve compared to healthy controls, but after 4 weeks of calcitriol treatment, this effect was significantly decreased, and there was a significant rise in the area under the insulin curve after glucose load. The insulinogenic index also increased significantly after calcitriol treatment.

Original languageEnglish
Pages (from-to)359-365
Number of pages7
Issue number6
Publication statusPublished - Jun 1994
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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