Hyperleptinemia positively correlated with metabolic syndrome in renal transplant recipients

Ming Che Lee, Chung Jen Lee, Guan Jin Ho, Chia Chi Lee, Ming Hui Shih, Kuei Chun Chou, Bang Gee Hsu

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Objective: Our aim was to evaluate the relationship between metabolic syndrome and fasting serum leptin concentration in renal transplant recipients. Patients and methods: Fasting blood samples were obtained from 55 renal transplant recipients. Metabolic syndrome and its components were defined using the diagnostic criteria of the International Diabetes Federation. Results: Thirteen patients (23.6%) had metabolic syndrome. Fasting leptin concentrations were positively correlated with metabolic syndrome (p = 0.003). Univariate linear regression analysis indicated fasting serum leptin values were positively correlated with waist circumference (r = 0.284; p = 0.036), body mass index (r = 0.358; p = 0.007), body fat mass (r = 0.610; p < 0.001), triglycerides (r = 0.268; p = 0.048), high-sensitivity C-reactive protein (hs-CRP) (r = 0.377; p = 0.005), triceps skinfold (r = 0.335; p = 0.012), and mid-arm fat area (r = 0.351; p = 0.009). Multivariate forward stepwise linear regression analysis of the significant variables revealed that body fat mass (R2 change = 0.373; p < 0.001) and hs-CRP (R2 change = 0.045; p = 0.049) were the independent predictors of fasting serum leptin concentration. Conclusion: Serum leptin concentration correlates positively with metabolic syndrome in renal transplant recipients.

Original languageEnglish
Pages (from-to)E124-E129
JournalClinical Transplantation
Issue number4
Publication statusPublished - Jul 2010
Externally publishedYes


  • Body fat mass
  • High-sensitive C-reactive protein
  • Kidney transplantation
  • Leptin
  • Metabolic syndrome

ASJC Scopus subject areas

  • Transplantation


Dive into the research topics of 'Hyperleptinemia positively correlated with metabolic syndrome in renal transplant recipients'. Together they form a unique fingerprint.

Cite this