Hyperleptinemia is associated with the aortic augmentation index in kidney transplant recipients

Yen Cheng Chen, Ming Che Lee, Chung Jen Lee, Bang Gee Hsu

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Objective: Increased circulating leptin, a marker of leptin resistance, is common in patients with obesity and is also an independent factor in prediction of cardiovascular disease. The aim of this study was to evaluate the relationship between fasting serum leptin levels and the aortic augmentation index (AIx) in kidney transplant recipients. Materials and Methods: Fasting blood samples were obtained from 70 kidney transplant recipients. The aortic AIx was measured using a validated tonometry system (SphygmoCor). Plasma leptin levels were measured using a commercial enzyme-linked immunosorbent assay kit. Results: Simple linear analysis of the aortic AIx in kidney transplant recipients showed that body fat mass (P = 0.002), diastolic blood pressure (DBP) (P = 0.020), logarithmically transformed triglycerides (P = 0.035), and leptin (P < 0.001) were positively correlated, while height (P = 0.004) and the glomerular filtration rate (P = 0.022) were negatively correlated with the aortic AIx in kidney transplant recipients. Forward stepwise linear regression analysis of the factors significantly associated with the aortic AIx showed that leptin (P < 0.001), DBP (P = 0.014), and body height (P = 0.036) were independent predictors of the aortic AIx in kidney transplant recipients. Conclusion: These results suggest that the serum fasting leptin level is associated with the aortic AIx in kidney transplant recipients.

Original languageEnglish
Pages (from-to)152-157
Number of pages6
JournalTzu Chi Medical Journal
Volume30
Issue number3
DOIs
Publication statusPublished - Jul 1 2018
Externally publishedYes

Keywords

  • Aortic augmentation index
  • Kidney transplantation
  • Leptin

ASJC Scopus subject areas

  • General Medicine

Fingerprint

Dive into the research topics of 'Hyperleptinemia is associated with the aortic augmentation index in kidney transplant recipients'. Together they form a unique fingerprint.

Cite this