Abstract
Hypercalcemia is a common complication of malignant diseases with or without bone metastasis. Hypercalcemia in prostate cancer is rarely seen. The exact mechanism of prostate cancer-related hypercalcemia is still uncertain. Secretion of parathyroid hormone-related peptides (PTH-rP) is thought to be one of the possible mechanisms. We reported a rare case of prostate cancer with hypercalcemia (13 mg/dL). Bone marrow biopsy showed metastatic adenocarcinoma. The cells were also positive for neuron-specific enolase, which is the specific marker for neuroendocrine cell. The finding suggested that the prostate cancer cell derived from the neuroendocrine cell, which might synthesize PTH-rP and be responsible for the observed hypercalcemia.
Original language | English |
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Pages (from-to) | 325-327 |
Number of pages | 3 |
Journal | Renal Failure |
Volume | 26 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2004 |
Externally published | Yes |
Keywords
- Hypercalcemia
- Neuron-specific enolase
- Parathyroid hormone-related peptide
- Prostate cancer
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
- Nephrology