Hypercalcemia and Lytic Bone Lesions in a Patient with B-Cell Non-Hodgkin's Lymphoma

Renee H. Jacobs, Richard A. Larson, Michelle Lebeau, Larry F. Kluskens, James W. Vardiman, Janet D. Rowley, Harvey M. Golomb, Paul A. Bunn, Geraldine P. Schechter, Jacqueline Whang-Peng, Elaine Jaffe, Robert Young, William Blattner, Samuel Broder, Robert C. Gallo

Research output: Contribution to journalLetterpeer-review

6 Citations (Scopus)


To the Editor: Bunn et al. comment that the presence of retrovirus-associated T-cell lymphomas should be strongly suspected on clinical grounds in patients who present with hypercalcemia and metabolic bone abnormalities (Aug. 4 issue).1 In August 1983, we evaluated a 29-year-old white man with painful lytic bone lesions, refractory hypercalcemia (16.0 mg per deciliter), and leukocytosis (53,000 per microliter); 42 percent of the circulating cells resembled poorly differentiated lymphoma cells with marked nuclear clefting and folding. Eleven years earlier the patient had received total-nodal irradiation for Hodgkin's disease (nodular sclerosing), followed two years later by MOPP (mechlorethamine, vincristine, procarbazine,.

Original languageEnglish
Pages (from-to)263-264
Number of pages2
JournalNew England Journal of Medicine
Issue number4
Publication statusPublished - Jan 26 1984
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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