Hyaluronic acid nanoparticles as nanomedicine for treatment of inflammatory diseases

N. Vijayakameswara Rao; Jun Gi Rho; Wooram Um; Pramod Kumar Ek; Van Quy Nguyen; Byeong Hoon Oh; Wook Kim; Jae Hyung Park

doi:10.3390/pharmaceutics12100931

Hyaluronic acid nanoparticles as nanomedicine for treatment of inflammatory diseases

N. Vijayakameswara Rao, Jun Gi Rho, Wooram Um, Pramod Kumar Ek, Van Quy Nguyen, Byeong Hoon Oh, Wook Kim, Jae Hyung Park

Ph.D. Program in Drug Discovery and Development Industry

Research output: Contribution to journal › Review article › peer-review

48 Citations (Scopus)

Abstract

Owing to their unique biological functions, hyaluronic acid (HA) and its derivatives have been explored extensively for biomedical applications such as tissue engineering, drug delivery, and molecular imaging. In particular, self-assembled HA nanoparticles (HA-NPs) have been used widely as target-specific and long-acting nanocarriers for the delivery of a wide range of therapeutic or diagnostic agents. Recently, it has been demonstrated that empty HA-NPs without bearing any therapeutic agent can be used therapeutically for the treatment of inflammatory diseases via modulating inflammatory responses. In this review, we aim to provide an overview of the significant achievements in this field and highlight the potential of HA-NPs for the treatment of inflammatory diseases.

Original language	English
Article number	931
Pages (from-to)	1-18
Number of pages	18
Journal	Pharmaceutics
Volume	12
Issue number	10
DOIs	https://doi.org/10.3390/pharmaceutics12100931
Publication status	Published - Oct 2020

Keywords

Atherosclerosis
Drug conjugates
Hyaluronic acid
Inflammatory diseases
Polymeric nanoparticles
Targeted-therapy
Tumor-targeting
Type 2 diabetes

ASJC Scopus subject areas

Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/pharmaceutics12100931

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title = "Hyaluronic acid nanoparticles as nanomedicine for treatment of inflammatory diseases",

abstract = "Owing to their unique biological functions, hyaluronic acid (HA) and its derivatives have been explored extensively for biomedical applications such as tissue engineering, drug delivery, and molecular imaging. In particular, self-assembled HA nanoparticles (HA-NPs) have been used widely as target-specific and long-acting nanocarriers for the delivery of a wide range of therapeutic or diagnostic agents. Recently, it has been demonstrated that empty HA-NPs without bearing any therapeutic agent can be used therapeutically for the treatment of inflammatory diseases via modulating inflammatory responses. In this review, we aim to provide an overview of the significant achievements in this field and highlight the potential of HA-NPs for the treatment of inflammatory diseases.",

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author = "Rao, {N. Vijayakameswara} and Rho, {Jun Gi} and Wooram Um and Ek, {Pramod Kumar} and Nguyen, {Van Quy} and Oh, {Byeong Hoon} and Wook Kim and Park, {Jae Hyung}",

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doi = "10.3390/pharmaceutics12100931",

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AU - Rao, N. Vijayakameswara

AU - Rho, Jun Gi

AU - Um, Wooram

AU - Ek, Pramod Kumar

AU - Nguyen, Van Quy

AU - Oh, Byeong Hoon

AU - Kim, Wook

AU - Park, Jae Hyung

PY - 2020/10

Y1 - 2020/10

N2 - Owing to their unique biological functions, hyaluronic acid (HA) and its derivatives have been explored extensively for biomedical applications such as tissue engineering, drug delivery, and molecular imaging. In particular, self-assembled HA nanoparticles (HA-NPs) have been used widely as target-specific and long-acting nanocarriers for the delivery of a wide range of therapeutic or diagnostic agents. Recently, it has been demonstrated that empty HA-NPs without bearing any therapeutic agent can be used therapeutically for the treatment of inflammatory diseases via modulating inflammatory responses. In this review, we aim to provide an overview of the significant achievements in this field and highlight the potential of HA-NPs for the treatment of inflammatory diseases.

AB - Owing to their unique biological functions, hyaluronic acid (HA) and its derivatives have been explored extensively for biomedical applications such as tissue engineering, drug delivery, and molecular imaging. In particular, self-assembled HA nanoparticles (HA-NPs) have been used widely as target-specific and long-acting nanocarriers for the delivery of a wide range of therapeutic or diagnostic agents. Recently, it has been demonstrated that empty HA-NPs without bearing any therapeutic agent can be used therapeutically for the treatment of inflammatory diseases via modulating inflammatory responses. In this review, we aim to provide an overview of the significant achievements in this field and highlight the potential of HA-NPs for the treatment of inflammatory diseases.

KW - Atherosclerosis

KW - Drug conjugates

KW - Hyaluronic acid

KW - Inflammatory diseases

KW - Polymeric nanoparticles

KW - Targeted-therapy

KW - Tumor-targeting

KW - Type 2 diabetes

KW - Atherosclerosis

KW - Drug conjugates

KW - Hyaluronic acid

KW - Inflammatory diseases

KW - Polymeric nanoparticles

KW - Targeted-therapy

KW - Tumor-targeting

KW - Type 2 diabetes

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Hyaluronic acid nanoparticles as nanomedicine for treatment of inflammatory diseases

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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