Human tissue kallikreins as prognostic biomarkers and as potential targets for anticancer therapy

Wun Shaing W. Chang; Ruey Hwang Chou; Cheng Wen Wu; Jang Yang Chang

doi:10.1517/13543776.17.10.1227

Human tissue kallikreins as prognostic biomarkers and as potential targets for anticancer therapy

Wun Shaing W. Chang, Ruey Hwang Chou, Cheng Wen Wu, Jang Yang Chang

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

The tissue kallikrein family represents the largest cluster of contiguous proteinase genes in the entire human genome. Its 15 members are expressed primarily in a tissue-specific manner, but can also be detected in biological fluids such as serum and seminal plasma. The mature active tissue kallikreins play vital roles in numerous physiological and pathological processes, in which they are able to function individually or in cascade pathway(s). Their genetic polymorphisms, alternative splicings and aberrant amounts of transcripts and/or proteins are often correlated with increased cancer risk, thus providing a sensible application for the use of tissue kallikreins as diagnostic, prognostic and predictive tumour markers. In this review, an updated overview of scientific research and patents regarding the functional features and clinical indications of tissue kallikreins in neoplastic diseases is provided.

Original language	English
Pages (from-to)	1227-1240
Number of pages	14
Journal	Expert Opinion on Therapeutic Patents
Volume	17
Issue number	10
DOIs	https://doi.org/10.1517/13543776.17.10.1227
Publication status	Published - Oct 2007
Externally published	Yes

Keywords

Kallikrein
Metastasis
Prognosis
Proteinase
Proteolytic enzyme
Serine proteinase
Tumour marker

ASJC Scopus subject areas

Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1517/13543776.17.10.1227

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title = "Human tissue kallikreins as prognostic biomarkers and as potential targets for anticancer therapy",

abstract = "The tissue kallikrein family represents the largest cluster of contiguous proteinase genes in the entire human genome. Its 15 members are expressed primarily in a tissue-specific manner, but can also be detected in biological fluids such as serum and seminal plasma. The mature active tissue kallikreins play vital roles in numerous physiological and pathological processes, in which they are able to function individually or in cascade pathway(s). Their genetic polymorphisms, alternative splicings and aberrant amounts of transcripts and/or proteins are often correlated with increased cancer risk, thus providing a sensible application for the use of tissue kallikreins as diagnostic, prognostic and predictive tumour markers. In this review, an updated overview of scientific research and patents regarding the functional features and clinical indications of tissue kallikreins in neoplastic diseases is provided.",

keywords = "Kallikrein, Metastasis, Prognosis, Proteinase, Proteolytic enzyme, Serine proteinase, Tumour marker",

author = "Chang, {Wun Shaing W.} and Chou, {Ruey Hwang} and Wu, {Cheng Wen} and Chang, {Jang Yang}",

note = "Funding Information: This article was supported by the National Health Research Institutes (grant numbers CA-095-PP-36 & CA-096-PP-27), Department of Health (grant number DOH95-TD-G-111-014) and National Science Council (grant numbers NSC93-3112-P-001-045 & NSC94-2752-B-007-004), Taipei, Taiwan. The authors are grateful to H-R Wu, H-F Yang, C-Y Yuan and S-C Lin for their generous help and assistance.",

year = "2007",

month = oct,

doi = "10.1517/13543776.17.10.1227",

language = "English",

volume = "17",

pages = "1227--1240",

journal = "Expert Opinion on Therapeutic Patents",

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AU - Chang, Wun Shaing W.

AU - Chou, Ruey Hwang

AU - Wu, Cheng Wen

AU - Chang, Jang Yang

N1 - Funding Information: This article was supported by the National Health Research Institutes (grant numbers CA-095-PP-36 & CA-096-PP-27), Department of Health (grant number DOH95-TD-G-111-014) and National Science Council (grant numbers NSC93-3112-P-001-045 & NSC94-2752-B-007-004), Taipei, Taiwan. The authors are grateful to H-R Wu, H-F Yang, C-Y Yuan and S-C Lin for their generous help and assistance.

PY - 2007/10

Y1 - 2007/10

N2 - The tissue kallikrein family represents the largest cluster of contiguous proteinase genes in the entire human genome. Its 15 members are expressed primarily in a tissue-specific manner, but can also be detected in biological fluids such as serum and seminal plasma. The mature active tissue kallikreins play vital roles in numerous physiological and pathological processes, in which they are able to function individually or in cascade pathway(s). Their genetic polymorphisms, alternative splicings and aberrant amounts of transcripts and/or proteins are often correlated with increased cancer risk, thus providing a sensible application for the use of tissue kallikreins as diagnostic, prognostic and predictive tumour markers. In this review, an updated overview of scientific research and patents regarding the functional features and clinical indications of tissue kallikreins in neoplastic diseases is provided.

AB - The tissue kallikrein family represents the largest cluster of contiguous proteinase genes in the entire human genome. Its 15 members are expressed primarily in a tissue-specific manner, but can also be detected in biological fluids such as serum and seminal plasma. The mature active tissue kallikreins play vital roles in numerous physiological and pathological processes, in which they are able to function individually or in cascade pathway(s). Their genetic polymorphisms, alternative splicings and aberrant amounts of transcripts and/or proteins are often correlated with increased cancer risk, thus providing a sensible application for the use of tissue kallikreins as diagnostic, prognostic and predictive tumour markers. In this review, an updated overview of scientific research and patents regarding the functional features and clinical indications of tissue kallikreins in neoplastic diseases is provided.

KW - Kallikrein

KW - Metastasis

KW - Prognosis

KW - Proteinase

KW - Proteolytic enzyme

KW - Serine proteinase

KW - Tumour marker

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DO - 10.1517/13543776.17.10.1227

M3 - Review article

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SN - 1354-3776

VL - 17

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JO - Expert Opinion on Therapeutic Patents

JF - Expert Opinion on Therapeutic Patents

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ER -

Human tissue kallikreins as prognostic biomarkers and as potential targets for anticancer therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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